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Correlated gene expression supports synchronous activity in brain networks

Authors
Jonas Richiardi,André Altmann
Anna-Clare Milazzo,Catie Chang,M. Chakravarty,Tobias Banaschewski,Gareth Barker,Arun Bokde,Uli Bromberg,Christian Büchel,Patricia Conrod,Mira Fauth‐Bühler,Herta Flor,Vincent Frouin,B. Musgrave,Hugh Garavan,Penny Gowland,Andreas Heinz,Hervé Lemaître,Karl Mann,Jean‐Luc Martinot,Frauke Nees,Tomáš Paus,Zdenka Pausová,Marcella Rietschel,Trevor Robbins,Michael Smolka,Rainer Spanagel,Andreas Ströhle,Günter Schumann,Michael Hawrylycz,Jean‐Baptiste Poline,Michael Greicius,Lisa Albrecht,Chris Andrew,Mercedes Arroyo,Éric Artiges,Semiha Aydın,Christine Bach,Alexis Barbot,Nathalie Boddaert,Zuleima Bricaud,Ruediger Bruehl,Arnaud Cachia,Anna Cattrell,Patrick Constant,Jeffrey Dalley,Benjamin Decideur,Sylvane Desrivières,Tahmine Fadai,Fanny Briand,Bert Heinrichs,Nadja Heym,Thomas Hübner,James Ireland,Bernd Ittermann,Tianye Jia,Mark Lathrop,Dirk Lanzerath,Claire Lawrence,Katharina Lüdemann,Christine Macare,Catherine Mallik,Jean‐François Mangin,J. Martinot,Eva Mennigen,Fabiana Carvahlo,Xavier Mignon,Rubén Miranda,Kathrin Müller,Charlotte Nymberg,Marie-Laure Paillère,Luise Poustka,Michael Rapp,Guillaume Robert,J.H. Reuter,Stephan Ripke,Sarah Jurk,John Rogers,Alexander Romanowski,Barbara Ruggeri,Christine Schmäl,Dirk Schmidt,Sophia Schneider,MarkGunter Schumann,Florian Schubert,Yannick Schwartz,Wolfgang Sommer,Claudia Speiser,Tade Spranger,Alicia Stedman,Sabina Steiner,D.N. Stephens,Nicole Strache,Maren Struve,Naresh Subramaniam,Lauren Topper,Robert Whelan,Steven Williams,Juliana Yacubian,Mônica Zilbovicius,Cybele Wong,Steven Lubbe,Lourdes Martinez-Medina,Alinda Fernandes,Amir Tahmasebi,Florian Holsboer
+105 authors
,Gunter Schümann
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Published
Jun 11, 2015
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Abstract

During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.

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