Abstract

Abstract Brain water proton ( 1 H 2 O) longitudinal relaxation time constants ( T 1 ) were obtained from three healthy individuals at magnetic field strengths ( B 0 ) of 0.2 Tesla (T), 1.0T, 1.5T, 4.0T, and 7.0T. A 5‐mm midventricular axial slice was sampled using a modified Look‐Locker technique with 1.5 mm in‐plane resolution, and 32 time points post‐adiabatic inversion. The results confirmed that for most brain tissues, T 1 values increased by more than a factor of 3 between 0.2T and 7T, and over this range were well fitted by T 1 (s) = 0.583( B 0 ) 0.382 , T 1 (s) = 0.857( B 0 ) 0.376 , and T 1 (s) = 1.35( B 0 ) 0.340 for white matter (WM), internal GM, and blood 1 H 2 O, respectively. The ventricular cerebrospinal fluid (CSF) 1 H 2 O T 1 value did not change with B 0 , and its average value (standard deviation (SD)) across subjects and magnetic fields was 4.3 (±0.2) s. The tissue 1/ T 1 values at each field were well correlated with the macromolecular mass fraction, and to a lesser extent tissue iron content. The field‐dependent increases in 1 H 2 O T 1 values more than offset the well‐known decrease in typical MRI contrast reagent (CR) relaxivity, and simulations predict that this leads to lower CR concentration detection thresholds with increased magnetic field. Magn Reson Med 57:308–318, 2007. © 2007 Wiley‐Liss, Inc.