Angewandte Chemie International EditionVolume 43, Issue 15 p. 1983-1986 Communication Asymmetric Direct Aldol Reaction Assisted by Water and a Proline-Derived Tetrazole Catalyst† Hiromi Torii, Hiromi Torii Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, JapanSearch for more papers by this authorMasakazu Nakadai Dr., Masakazu Nakadai Dr. Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, JapanSearch for more papers by this authorKazuaki Ishihara Prof. Dr., Kazuaki Ishihara Prof. Dr. Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, JapanSearch for more papers by this authorSusumu Saito Prof. Dr., Susumu Saito Prof. Dr. susumu@chem.nagoya-u.ac.jp Institute for Advanced Research & Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, Fax: (+81) 527-895-945Search for more papers by this authorHisashi Yamamoto Prof. Dr., Hisashi Yamamoto Prof. Dr. yamamoto@uchicago.edu Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, IL 60637, USA, Fax: (+1) 773-702-0805Search for more papers by this author Hiromi Torii, Hiromi Torii Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, JapanSearch for more papers by this authorMasakazu Nakadai Dr., Masakazu Nakadai Dr. Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, JapanSearch for more papers by this authorKazuaki Ishihara Prof. Dr., Kazuaki Ishihara Prof. Dr. Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, JapanSearch for more papers by this authorSusumu Saito Prof. Dr., Susumu Saito Prof. Dr. susumu@chem.nagoya-u.ac.jp Institute for Advanced Research & Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, Fax: (+81) 527-895-945Search for more papers by this authorHisashi Yamamoto Prof. Dr., Hisashi Yamamoto Prof. Dr. yamamoto@uchicago.edu Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, IL 60637, USA, Fax: (+1) 773-702-0805Search for more papers by this author First published: 30 March 2004 https://doi.org/10.1002/anie.200352724Citations: 513 † We thank H. Ishibashi (Nagoya) and Dr. K. Yoza (Bruker, AXS) for performing X-ray single-crystal analyses, and Professor A. Yamamoto and N. Tamura (JST) for their support and valuable advice. This work was supported by SORST and by the Japan Science and Technology Corporation (JST). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Just add water to improve the performance of direct aldol reactions like that shown. Previously, aldehydes with high water-affinity or -solubility were considered unsuitable for asymmetric synthesis. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z52724_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume43, Issue15April 2, 2004Pages 1983-1986 RelatedInformation

Asymmetric Direct Aldol Reaction Assisted by Water and a Proline‐Derived Tetrazole Catalyst