7-Benzyl-1,5-dimethyl-3-piperonyloyl-3,7-diazabicyclo[3.3.1]nonan-9-one as an allosteric modulator of glutamatergic system

Abstract

The title compound has been synthesized and assessed in vitro by means of electrophysiological patch clamp technique revealing a positive modulatory effect on the kainate-induced currents in Purkinje neurons in a wide concentration range from 10–12 to 10–6 m. Molecular docking and molecular dynamics simulation revealed a putative binding mode of this compound in the binding site of positive allosteric modulators of AMPA receptors.