Abstract

Angewandte Chemie International EditionVolume 51, Issue 44 p. 11039-11043 Communication Ceria Nanoparticles that can Protect against Ischemic Stroke† Dr. Chi Kyung Kim, Dr. Chi Kyung Kim Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea) These authors contributed equally to this work.Search for more papers by this authorTaeho Kim, Taeho Kim Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea) These authors contributed equally to this work.Search for more papers by this authorIn-Young Choi, In-Young Choi Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorMin Soh, Min Soh Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this authorDr. Dohoung Kim, Dr. Dohoung Kim Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorYoung-Ju Kim, Young-Ju Kim Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorDr. Hyunduk Jang, Dr. Hyunduk Jang Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorHye-Sung Yang, Hye-Sung Yang Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorDr. Jun Yup Kim, Dr. Jun Yup Kim Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorDr. Hong-Kyun Park, Dr. Hong-Kyun Park Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorDr. Seung Pyo Park, Dr. Seung Pyo Park Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this authorSangseung Park, Sangseung Park Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this authorDr. Taekyung Yu, Dr. Taekyung Yu Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this authorProf. Byung-Woo Yoon, Prof. Byung-Woo Yoon Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorProf. Seung-Hoon Lee, Corresponding Author Prof. Seung-Hoon Lee [email protected] Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea) Seung-Hoon Lee, Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea) Taeghwan Hyeon, Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this authorProf. Taeghwan Hyeon, Corresponding Author Prof. Taeghwan Hyeon [email protected] Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea) Seung-Hoon Lee, Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea) Taeghwan Hyeon, Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this author Dr. Chi Kyung Kim, Dr. Chi Kyung Kim Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea) These authors contributed equally to this work.Search for more papers by this authorTaeho Kim, Taeho Kim Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea) These authors contributed equally to this work.Search for more papers by this authorIn-Young Choi, In-Young Choi Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorMin Soh, Min Soh Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this authorDr. Dohoung Kim, Dr. Dohoung Kim Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorYoung-Ju Kim, Young-Ju Kim Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorDr. Hyunduk Jang, Dr. Hyunduk Jang Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorHye-Sung Yang, Hye-Sung Yang Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorDr. Jun Yup Kim, Dr. Jun Yup Kim Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorDr. Hong-Kyun Park, Dr. Hong-Kyun Park Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorDr. Seung Pyo Park, Dr. Seung Pyo Park Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this authorSangseung Park, Sangseung Park Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this authorDr. Taekyung Yu, Dr. Taekyung Yu Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this authorProf. Byung-Woo Yoon, Prof. Byung-Woo Yoon Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)Search for more papers by this authorProf. Seung-Hoon Lee, Corresponding Author Prof. Seung-Hoon Lee [email protected] Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea) Seung-Hoon Lee, Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea) Taeghwan Hyeon, Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this authorProf. Taeghwan Hyeon, Corresponding Author Prof. Taeghwan Hyeon [email protected] Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea) Seung-Hoon Lee, Department of Neurology, Seoul National University Hospital, and Department of Neurology, College of Medicine and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 110-744 (Korea) Taeghwan Hyeon, Center for Nanoparticle Research, Institute for Basic Science (IBS), and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 (Korea)Search for more papers by this author First published: 11 September 2012 https://doi.org/10.1002/anie.201203780Citations: 385 † This work was supported by a grant of the Korean Health Technology R&D Project, Korean Ministry of Health & Welfare (A111014). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201203780_sm_miscellaneous_information.pdf6.5 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume51, Issue44October 29, 2012Pages 11039-11043 RelatedInformation