Abstract Microbial cells need to adapt to changing environmental conditions to survive. There is an evolutionary advantage to grow fast; this requires high metabolic rates, and an efficient allocation of enzymatic resources. Here we study a general control theory called q ORAC, developed previously, which allows cells to adaptively control their enzyme allocations to achieve maximal steady state flux. The control is robust to perturbations in the environment, but those perturbations themselves do not feature in the control. In this paper we focus on the archetypical pathway, the linear chain with reversible Michaelis-Menten kinetics, together with q ORAC control. First we assume that the metabolic pathway is in quasi-steady state with respect to enzyme synthesis. Then we show that the map between steady state metabolite and enzyme concentrations is a smooth bijection. Using this information, we finally show that the unique (and hence flux-maximising) steady state of this system is locally stable. We provide further evidence that it may in fact be globally stable.

Stability of an adaptively controlled pathway maximising specific flux under varying conditions