Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
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Authors
Joshua Milner
Joshua Milner•Tiphanie Vogel•Megan Cooper
Published
October 31, 2014
Abstract
Key Points Germline gain-of-function mutations in STAT3 lead to lymphoproliferation and autoimmunity with prominent cytopenias. Mutations in STAT3 cause altered regulatory T cells and cytokine signaling.
