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Paper

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In vivo loss of telomeric repeats with age in humans | ResearchHub

Paper

Paper

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Journal

Mutation Research/DNAging

Topics

Molecular Biology

DOI

10.1016/0921-8734(91)90032-7

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In vivo loss of telomeric repeats with age in humans

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Authors

Janet Lindsey

Janet Lindsey•Niolette McGill•Howard Cooke

Published

January 1, 1991

Abstract

Telomeric DNA in the skin cells of 21 human subjects aged between 0 and 92 years was quantified by determining the length of the telomeric smear and the relative amount of TTAGGG repeat sequences. Both telomere length and quantity of telomeric repeat sequences were found to decrease significantly with age. Telomere loss has previously been postulated to be a caused of cell senescence.

Supporters

Support the authors with ResearchCoin

Journal

Mutation Research/DNAging

Topics

Molecular Biology

DOI

10.1016/0921-8734(91)90032-7