NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)
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Authors
Rizwan Romee
Rizwan Romee•Bree Foley•Jeffrey Miller
Published
March 14, 2013
Abstract
Key Points Activated NK cells loose CD16 (FcRγIII) and CD62L through a metalloprotease called ADAM17. Inhibition of ADAM17 enhances CD16 mediated NK cell function by preserving CD16 on the NK cell surface to enhance ADCC.
