Abstract

Objective: To describe the relation between maternal obesity, overweight and underweight status, and 16 categories of structural birth defects.Design: An ongoing multisite, case-control study.Clinical geneticists reviewed all of the cases, excluding those that had or were strongly suspected to have a single-gene disorder or chromosomal abnormality.Mothers with preexisting diabetes were also excluded.Body mass index was based on maternal report of height and weight prior to pregnancy.Setting: Eight participating states in the United States.