Abstract

CancerVolume 63, Issue 1 p. 1-13 ArticleFree Access Alveolar soft-part sarcoma. A clinico-pathologic study of half a century Philip H. Lieberman MD, Corresponding Author Philip H. Lieberman MD Departments of Pathology, New York, New YorkChief, Surgical Pathology Service, Memorial Hospital, 1275 York Avenue. New York, NY 10021===Search for more papers by this authorMurray F. Brennan MD, Murray F. Brennan MD Departments of Surgery. Memorial Sloan-Kettering Cancer Center, New York, New YorkSearch for more papers by this authorMarek Kimmel PhD, Marek Kimmel PhD Departments of Pathology, New York, New YorkSearch for more papers by this authorRobert A. Erlandson PhD, Robert A. Erlandson PhD Departments of Pathology, New York, New YorkSearch for more papers by this authorPilar Garin-Chesa MD, PhD, Pilar Garin-Chesa MD, PhD Departments of Pathology, New York, New YorkSearch for more papers by this authorBetty Y. Flehinger PhD, Betty Y. Flehinger PhD Mathematical Sciences Department, IBM Thomas J. Watson Research Center, York-town Heights, New YorkSearch for more papers by this author Philip H. Lieberman MD, Corresponding Author Philip H. Lieberman MD Departments of Pathology, New York, New YorkChief, Surgical Pathology Service, Memorial Hospital, 1275 York Avenue. New York, NY 10021===Search for more papers by this authorMurray F. Brennan MD, Murray F. Brennan MD Departments of Surgery. Memorial Sloan-Kettering Cancer Center, New York, New YorkSearch for more papers by this authorMarek Kimmel PhD, Marek Kimmel PhD Departments of Pathology, New York, New YorkSearch for more papers by this authorRobert A. Erlandson PhD, Robert A. Erlandson PhD Departments of Pathology, New York, New YorkSearch for more papers by this authorPilar Garin-Chesa MD, PhD, Pilar Garin-Chesa MD, PhD Departments of Pathology, New York, New YorkSearch for more papers by this authorBetty Y. Flehinger PhD, Betty Y. Flehinger PhD Mathematical Sciences Department, IBM Thomas J. Watson Research Center, York-town Heights, New YorkSearch for more papers by this author First published: 1 January 1989 https://doi.org/10.1002/1097-0142(19890101)63:13.0.CO;2-ECitations: 327AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract In the period from 1923 to 1986 our pathologists examined pathologic material from 102 patients with alveolar soft-part sarcoma (ASPS). Followup clinical data is available for 91. Median followup is 7 years (range 1 month to 27 years). Local recurrence was only found if residual disease was left at the time of the original excision. Survival in those patients who presented without metastases was 77% at 2 years, 60% at 5 years, 38% at 10 years and 15% at 20 years (median 6 years). No survival advantage could be demonstrated for patients who received chemo and/or radiotherapy, although numbers are small and staging not uniform. An evaluation by electron microscopy and immunohistochemistry cannot confirm recent claims that ASPS is a muscle tumor. ASPS is an unusual neoplasm; the primary therapeutic option is aggressive surgical excision. Survival even with the development of metastases can be long. Reference 1 Christopherson WM, Foote FW Jr, Stewart FW. Alveolar soft-part sarcomas; structurally characteristic tumors of uncertain histogenesis. Cancer 1952; 5: 100–111. 2 Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. 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