Paper
Document
Download
Flag content
1

Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke

1
TipTip
Save
Document
Download
Flag content

Abstract

Significance Patients suffering from ischemic strokes have limited therapeutic options and are often left with considerable disabilities. To promote neurological recovery, angiogenesis has been proposed as a promising therapeutic target. So far, experimental efforts to enhance vessel growth have almost exclusively focused on vascular growth factor supplementation; this approach has been shown not to be clinically viable due to hemorrhagic risks. Here, we pursued an alternative approach by targeting the guidance molecule Nogo-A, which has been recently shown to inhibit developmental central nervous system angiogenesis. Blockage of the Nogo-A pathway results in restoration of a mature vascular bed within the periinfarct zone. Moreover, we observe enhanced recovery-associated tissue responses and regain of motor functions that strongly correlate with vascular growth.

Paper PDF

This paper's license is marked as closed access or non-commercial and cannot be viewed on ResearchHub. Visit the paper's external site.