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OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
Biochemistry
Immunology
Pharmacology
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Authors
Carlo Marchetti
,
Benjamin Swartzwelter
Fabia Gamboni
,
C. Neff
,
Katrin Richter
,
Tania Azam
,
Sonia Carta
,
Isak Tengesdal
,
Travis Nemkov
,
Angelo D’Alessandro
,
Curtis Henry
,
Gerald Jones
,
Scott Goodrich
,
Joseph Laurent
,
Terry Jones
,
Curtis Scribner
,
Robert Barrow
,
Roy Altman
,
Damaris Skouras
,
Marco Gattorno
,
Veronika Grau
,
Sabina Janciauskiene
,
Anna Rubartelli
,
Leo Joosten
+22 authors
,
Charles Dinarello
Journal
Proceedings of the National Academy of Sciences
Published
Jan 29, 2018
DOI
10.1073/pnas.1716095115
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