Abstract

ARTICLESAction of secretagogues on a new preparation of functionally intact, isolated pancreatic aciniJohn A. Williams, Murray Korc, and Robert L. DormerJohn A. Williams, Murray Korc, andRobert L. DormerPublished Online:01 Nov 1978https://doi.org/10.1152/ajpendo.1978.235.5.E517MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation CollectionsAPS Cross-Journal Collections125th Anniversary Collection Cited ByThe effect of bile acid TLC-S vitality of pantacric acinary cells and level of mitochondrial membrane potential13 October 2023 | Visnyk of Lviv University. 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Animal models of acute and chronic pancreatitisXianbao Zhan*, Fan Wang*, Yan Bi, andBaoan Ji1 September 2016 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 311, No. 3Glucagon-like peptide-1 receptor is present in pancreatic acinar cells and regulates amylase secretion through cAMPYanan Hou, Stephen A. Ernst, Kaeli Heidenreich, andJohn A. Williams1 January 2016 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 310, No. 1Pancreatic Secretion27 November 2015Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor's Beneficial Effect in Rats: Role of MRP4 (ABCC4)6 January 2015 | Molecular Medicine, Vol. 21, No. 1Glutamate formation via the leucine-to-glutamate pathway of rat pancreasDavid Schachter, andJean Buteau1 June 2014 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 306, No. 11Cholecystokinin and pancreatic cancer: the chicken or the egg?Jill P. Smith, andTravis E. Solomon15 January 2014 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 306, No. 2Mechanisms of respiration intensification of rat pancreatic acini upon carbachol‐induced Ca 2+ release11 June 2013 | Acta Physiologica, Vol. 208, No. 4Directing exocrine secretory vesicles to the apical membrane by actin cables generated by the formin mDia110 June 2013 | Proceedings of the National Academy of Sciences, Vol. 110, No. 26An implication of novel methodology to study pancreatic acinar mitochondria under in situ conditions13 August 2012 | Cell Biochemistry and Function, Vol. 31, No. 2c-Jun/AP-1 is required for CCK-induced pancreatic acinar cell dedifferentiation and DNA synthesis in vitroLili Guo, Maria Dolors Sans, Yanan Hou, Stephen A. Ernst, andJohn A. Williams15 June 2012 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 302, No. 12Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injuryKamaldeen A. Muili, Mahwish Ahmad, Abrahim I. Orabi, Syeda M. Mahmood, Ahsan U. Shah, Jeffery D. Molkentin, andSohail Z. Husain15 April 2012 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 302, No. 8Atrial Natriuretic Factor Stimulates Efflux of cAMP in Rat Exocrine Pancreas via Multidrug Resistance–Associated ProteinsGastroenterology, Vol. 140, No. 4Parimal Chowdhury's work on smoking related pancreatic disordersWorld Journal of Gastrointestinal Pathophysiology, Vol. 2, No. 3CCK activates RhoA and Rac1 differentially through Gα13 and Gαq in mouse pancreatic aciniMaria E. Sabbatini, Yan Bi*, Baoan Ji, Stephen A. Ernst, andJohn A. Williams1 March 2010 | American Journal of Physiology-Cell Physiology, Vol. 298, No. 3The calcium binding protein S100A9 is essential for pancreatic leukocyte infiltration and induces disruption of cell–cell contacts1 May 2008 | Journal of Cellular Physiology, Vol. 216, No. 2Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue‐induced trypsinogen and NF‐κB activation16 October 2007 | Journal of Cellular Physiology, Vol. 215, No. 1Ca2+ release dynamics in parotid and pancreatic exocrine acinar cells evoked by spatially limited flash photolysisJong Hak Won*, William J. Cottrell*, Thomas H. Foster, andDavid I. Yule1 December 2007 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 293, No. 6C-type natriuretic peptide enhances amylase release through NPR-C receptors in the exocrine pancreasMaría E. Sabbatini, Myrian Rodríguez, María B. di Carlo, Carlos A. Davio, Marcelo S. Vatta, andLiliana G. Bianciotti1 November 2007 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 293, No. 5Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cellsConstanze H. Kubisch, andCraig D. Logsdon1 June 2007 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 292, No. 6How does cholecystokinin stimulate exocrine pancreatic secretion? From birds, rodents, to humansBi Jue Wang, andZong Jie Cui1 February 2007 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 292, No. 2Nicotine‐induced proliferation of isolated rat pancreatic acinar cells: effect on cell signalling and function15 January 2007 | Cell Proliferation, Vol. 40, No. 1Atrial natriuretic factor negatively modulates secretin intracellular signaling in the exocrine pancreasMaría E. Sabbatini, Marcelo S. Vatta, Carlos A. Davio, andLiliana G. Bianciotti1 January 2007 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 292, No. 1Measurement of Ca2+ signaling dynamics in exocrine cells with total internal reflection microscopyJong Hak Won, andDavid I. Yule1 July 2006 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 291, No. 1Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitisShinya Ohashi, Akiyoshi Nishio, Hajime Nakamura, Masahiro Kido, Satoru Ueno, Norimitsu Uza, Satoko Inoue, Hiroshi Kitamura, Keiichi Kiriya, Masanori Asada, Hiroyuki Tamaki, Minoru Matsuura, Kimio Kawasaki, Toshiro Fukui, Norihiko Watanabe, Hiroshi Nakase, Junji Yodoi, Kazuichi Okazaki, andTsutomu Chiba1 April 2006 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 290, No. 4A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations30 January 2006 | Proceedings of the National Academy of Sciences, Vol. 103, No. 6Expression of pro-Muclin in pancreatic AR42J cells induces functional regulated secretory granulesRobert C. De Lisle, Oxana Norkina, Eileen Roach, andDonna Ziemer1 November 2005 | American Journal of Physiology-Cell Physiology, Vol. 289, No. 5Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretionYan Bi, Sophie Le Page, andJohn A. Williams1 September 2005 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 289, No. 3A role for Rho and Rac in secretagogue-induced amylase release by pancreatic aciniYan Bi, andJohn A. Williams1 July 2005 | American Journal of Physiology-Cell Physiology, Vol. 289, No. 1Agonist activation of arachidonate‐regulated Ca 2+ ‐selective (ARC) channels in murine parotid and pancreatic acinar cells21 April 2005 | The Journal of Physiology, Vol. 564, No. 3Regulation of CCK-induced amylase release by PKC-δ in rat pancreatic acinar cellsChenwei Li, Xuequn Chen, andJohn A. Williams1 October 2004 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 287, No. 4Identification of nonsulfated cholecystokinin-58 in canine intestinal extracts and its biological propertiesJoseph R. Reeve, Rodger A. Liddle, Douglas C. McVey, Steven R. Vigna, Travis E. Solomon, David A. Keire, Grace Rosenquist, John E. Shively, Terry D. Lee, Peter Chew, Gary M. Green, andTamer Coskun1 August 2004 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 287, No. 2Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in miceMatthew J. DiMagno, Yibai Hao, Yasuhiro Tsunoda, John A. Williams, andChung Owyang1 March 2004 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 286, No. 3Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptorsMaría E. Sabbatini, Alberto Villagra, Carlos A. Davio, Marcelo S. Vatta, Belisario E. Fernández, andLiliana G. Bianciotti1 November 2003 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 285, No. 5Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cellsDavid A. Brown, James E. Melvin, andDavid I. Yule1 November 2003 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 285, No. 5Association of Small GTP-binding Protein, RhoA with Adherens Junction Proteins, E-cadherin and ^|^beta;-catenin in Pancreatic AciniThe Showa University Journal of Medical Sciences, Vol. 15, No. 2Cholecystokinin Activates a Variety of Intracellular Signal Transduction Mechanisms in Rodent Pancreatic Acinar Cells28 January 2003 | Pharmacology & Toxicology, Vol. 91, No. 6Cytosolic Ca 2+ and Ca 2+ ‐activated Cl − current dynamics: insights from two functionally distinct mouse exocrine cells1 April 2002 | The Journal of Physiology, Vol. 540, No. 2Trypsin activity is not involved in premature, intrapancreatic trypsinogen activationWalter Halangk, Burkhard Krüger, Manuel Ruthenbürger, Jörg Stürzebecher, Elke Albrecht, Hans Lippert, andMarkus M. Lerch1 February 2002 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 282, No. 2Polarized Calcium and Calmodulin Signaling in Secretory EpitheliaMichael C. Ashby, andAlexei V. Tepikin7 January 2002 | Physiological Reviews, Vol. 82, No. 3Inhibition of pancreatic protein secretion by ghrelin in the rat1 November 2001 | The Journal of Physiology, Vol. 537, No. 1Calcium‐magnesium interactions in pancreatic acinar cells1 March 2001 | The FASEB Journal, Vol. 15, No. 3Cell‐specific Localization of the Cholecystokinin A Receptor in the Porcine Pancreas7 July 2008 | Anatomia, Histologia, Embryologia, Vol. 29, No. 6Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells21 November 2000 | Proceedings of the National Academy of Sciences, Vol. 97, No. 24Response of Rat Exocrine Pancreas to High‐Fat and High‐Carbohydrate Diets18 July 2008 | Proceedings of the Society for Experimental Biology and Medicine, Vol. 223, No. 3Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic aciniA. K. Saluja, L. Bhagat, H. S. Lee, M. Bhatia, J. L. Frossard, andM. L. Steer1 April 1999 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 276, No. 4Calcium signaling in rat pancreatic acinar cells: a role for Gαq, Gα11, and Gα14David I. Yule, Christopher W. Baker, andJohn A. Williams1 January 1999 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 276, No. 1Optical measurement of stimulus-evoked membrane dynamics in single pancreatic acinar cellsDavid R. Giovannucci, David I. Yule, andEdward L. Stuenkel1 September 1998 | American Journal of Physiology-Cell Physiology, Vol. 275, No. 3The Trophic Response of Rat Pancreas to Sulfated Cholecystokinin‐8 is Dose‐ and Time‐Dependent and Not Affected by Vagotomy or Atropine25 March 2009 | Pharmacology & Toxicology, Vol. 80, No. 3Morphological identification of and collagen synthesis by periacinar fibroblastoid cells cultured from isolated rat pancreatic aciniJournal of Gastroenterology, Vol. 31, No. 4Heterogeneity and contact‐dependent regulation of amylase release by individual acinar cells4 February 2005 | Journal of Cellular Physiology, Vol. 160, No. 2Study of the states and populations of the rat pancreatic cholecystokinin receptor using the full peptide antagonist JMV 1793 March 2005 | European Journal of Biochemistry, Vol. 212, No. 2Analysis of Intracellular Movement of Synthetic Protease Inhibitor (E3123) by Electronmicroscopic Autoradiography of Rat Isolated Pancreatic AciniThe Japanese Journal of Gastroenterological Surgery, Vol. 26, No. 10Characterization of interactions between CCK‐33 and CCK receptors in isolated dispersed pancreatic acini4 February 2005 | Journal of Cellular Physiology, Vol. 153, No. 3' In vitro ' action of histamine and cimetidine on amylase secretion in the rat pancreas7 February 2006 | Biopharmaceutics & Drug Disposition, Vol. 13, No. 5Selective Release of Somatostatin by Calcitonin Gene—Related Peptide and Influence on Pancreatic Secretiona17 December 2006 | Annals of the New York Academy of Sciences, Vol. 657, No. 1Combined dose‐ratio analysis of cholecystokinin receptor antagonists, devazepide, lorglumide and loxiglumide in the guinea‐pig gall bladder19 July 2012 | British Journal of Pharmacology, Vol. 106, No. 1Measurement of tissue cholecystokinin (CCK) concentrations by bioassay and specific radioimmunoassay: characterization of the bioactivity of CCK‐58 before and after tryptic cleavage28 June 2008 | European Journal of Clinical Investigation, Vol. 20, No. 1Long‐Term Regulation of Pancreatic Function Studied in Vitro1 January 2011Oscillations of cytosolic calcium in single pancreatic acinar cells stimulated by acetylcholine14 November 2001 | FEBS Letters, Vol. 239, No. 2Cholecystokinic activity of N α‐hydroxysulfonyl‐[Nle 28,31 ]CCK 26‐33 analogues modified at the C ‐terminal residue12 January 2009 | International Journal of Peptide and Protein Research, Vol. 31, No. 6Neuroendocrine Control of Secretion in Pancreatic and Parotid Gland Acini and the Role of Na+,K+-ATPase ActivityResidual inhibition of epidermal growth factor binding by pancreatic secretagogues and phorbol ester in rat pancreas4 February 2005 | Journal of Cellular Physiology, Vol. 124, No. 2Reversible acetaldehyde inhibition of A23187‐stimulated amylase secretion from isolated rat pancreatic acini5 November 2001 | FEBS Letters, Vol. 184, No. 2Phorbol ester induces intracellular translocation of phospholipid/Ca 2+ ‐dependent protein kinase and stimulates amylase secretion in isolated pancreatic acini12 November 2001 | FEBS Letters, Vol. 171, No. 2Action of the venom of the scorpion Tityus trinitatis on pancreatic insulin secretionBiochemical Pharmacology, Vol. 32, No. 6The CCK receptor on pancreatic plasma membranes: binding characteristics and covalent cross‐linking29 October 2001 | FEBS Letters, Vol. 151, No. 1 More from this issue > Volume 235Issue 5November 1978Pages E517-524 Copyright & PermissionsCopyright © 1978 by American Physiological Societyhttps://doi.org/10.1152/ajpendo.1978.235.5.E517History Published online 1 November 1978 Published in print 1 November 1978 Metrics