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Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma
Authors
Brian Walker,Konstantinos Mavrommatis
Christopher Wardell,Cody Ashby,Michael Bauer,Faith Davies,Adam Rosenthal,Hongwei Wang,Pingping Qu,Antje Hoering,Mehmet Samur,Fadi Towfic,María Ortiz,Erin Flynt,Zhinuan Yu,Zhihong Yang,Dan Rozelle,John Obenauer,Matthew Trotter,Daniel Auclair,Jonathan Keats,Niccolò Bolli,Mariateresa Fulciniti,Raphaël Szalat,Philippe Moreau,Brian Durie,A. Stewart,Hartmut Goldschmidt,Marc Raab,Hermann Einsele,Pieter Sonneveld,Jesús Miguel,Sagar Lonial,Graham Jackson,Kenneth Anderson,Hervé Avet‐Loiseau,Nikhil Munshi,Anjan Thakurta,Gareth Morgan
+37 authors
,Konstantinos MavromatisJournal
Published
Jun 8, 2018
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Abstract
Key Points Using the largest set of patients with newly diagnosed myeloma, we identified 63 mutated driver genes. We identified oncogenic dependencies, particularly relating to primary translocations, indicating a nonrandom accumulation of genetic hits.
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