The sesquiterpenoid lactone phytoalexin lettucenin A was isolated from seedlings of lettuce with the red spot physiological disorder. Accumulation of lettucenin A was preceded by increased activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase. The red spot syndrome may provide a tractable mimic of the hypersensitive reaction of lettuce to microbial challenge.
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