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Differential impact of allelic ratio and insertion site in FLT3-ITD–positive AML with respect to allogeneic transplantation
Authors
Richard Schlenk,Sabine Käyser
Lars Bullinger,Guido Kobbe,Jochen Casper,Mark Ringhoffer,Gerhard Held,Peter Brossart,Michael Lübbert,Helmut Salih,Thomas Kindler,Heinz Horst,Gerald Wulf,David Nachbaur,Katharina Götze,Alexander Lamparter,Peter Paschka,Verena Gaidzik,Veronica Teleanu,Daniela Späth,Axel Benner,Jürgen Krauter,Arnold Ganser,Hartmut Döhner
+22 authors
,Konstanze DöhnerJournal
Published
Oct 1, 2014
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Abstract
Key Points In FLT3-ITD–positive AML, high allelic ratio and ITD insertion site in TKD1 predict for low complete remission rates and poor survival. In FLT3-ITD–positive AML, allogeneic HSCT in first CR outweighs the negative impact of high allelic ratio on survival.
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