Abstract

Research Article1 July 1987free access Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. K. Suzuki K. Suzuki Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author H. Kusumoto H. Kusumoto Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author Y. Deyashiki Y. Deyashiki Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author J. Nishioka J. Nishioka Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author I. Maruyama I. Maruyama Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author M. Zushi M. Zushi Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author S. Kawahara S. Kawahara Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author G. Honda G. Honda Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author S. Yamamoto S. Yamamoto Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author S. Horiguchi S. Horiguchi Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author K. Suzuki K. Suzuki Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author H. Kusumoto H. Kusumoto Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author Y. Deyashiki Y. Deyashiki Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author J. Nishioka J. Nishioka Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author I. Maruyama I. Maruyama Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author M. Zushi M. Zushi Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author S. Kawahara S. Kawahara Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author G. Honda G. Honda Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author S. Yamamoto S. Yamamoto Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author S. Horiguchi S. Horiguchi Department of Laboratory Medicine, Mie University School of Medicine, Japan. Search for more papers by this author Author Information K. Suzuki1, H. Kusumoto1, Y. Deyashiki1, J. Nishioka1, I. Maruyama1, M. Zushi1, S. Kawahara1, G. Honda1, S. Yamamoto1 and S. Horiguchi1 1Department of Laboratory Medicine, Mie University School of Medicine, Japan. The EMBO Journal (1987)6:1891-1897https://doi.org/10.1002/j.1460-2075.1987.tb02448.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We have deduced the entire 575-amino acid sequence of the human thrombomodulin precursor from cDNA clones. The precursor starts with an 18-residue signal peptide domain, followed by the NH2-terminal domain, a domain with six epidermal growth factor-like structures, an O-glycosylation site-rich domain, a 24-residue transmembrane domain and a cytoplasmic domain. Simian COS cells transfected with the expression vector pSV2 containing thrombomodulin cDNA synthesized immunoreactive and functionally active thrombomodulin. Previous ArticleNext Article Volume 6Issue 71 July 1987In this issue RelatedDetailsLoading ...