Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

Isabelle Solomon,Kroopa Joshi,Leila Mekkaoui,Marta Lesko,Enrique Miranda,Rony Dahan,Andrew Georgiou,Anna Śledzińska,Assma Aïssa,Dafne Franz,Mariana Sunderland,Yien Wong,Jake Henry,Tim O’Brien,David Nicol,Ben Challacombe,Stephen Beers,Samra Turajlic,Martin Gore,James Larkin,Charles Swanton,Kerry Chester,Martin Pulè,Jeffrey Ravetch,Teresa Marafioti,Karl Peggs,Sergio Quezada,Lavinia Spain,Andrew Wotherspoon,Nick Francis,Myles Smith,D. Strauß,Andrew Hayes,Aspasia Soultati,Mark Stares,Joanna Lynch,Nicos Fotiadis,Archana Fernando,Steve Hazell,Ashish Chandra,Lisa Pickering,Sarah Rudman,Simon Chowdhury,Mariam Jamal‐Hanjani,Selvaraju Veeriah,Seema Shafi,Justyna Czyzewska-Khan,Diana Johnson,Joanne Laycock,Leticia Bosshard‐Carter,Gerald Goh,Rachel Rosenthal,Pat Gorman,Nirupa Murugaesu,Robert Hynds,Gareth Wilson,Nicolai Birkbak,Thomas Watkins,Nicholas McGranahan,Stuart Horswell,Richard Mitter,Mickael Escudero,Aengus Stewart,Peter Loo,Andrew Rowan,Hang Xu,Crispin Hiley,Christopher Abbosh,Jacki Goldman,Richard Stone,Tamara Denner,Nik Matthews,Greg Elgar,Martin Hayward,Jennifer Biggs,Marta Costa,Sharmin Begum,Ben Phillimore,Tim Chambers,Emma Nye,Sofia Graca,Maise Bakir,John Hartley,Helen Lowe,Javier Herrero,David Lawrence,Nikolaos Panagiotopoulos,Shyam Kolvekar,Mary Falzon,Elaine Borg,Celia Simeon,Gemma Hector,Amy Smith,Marie Aranda,Marco Novelli,Dahmane Oukrif,Sam Janes,Ricky Thakrar,Martin Förster,Tanya Ahmad,Siow Lee,Dionysis Papadatos-Pastos,Dawn Carnell,R. Mendes,Jeremy George,Neal Navani,Asia Ahmed,Magali Taylor,Junaid Choudhary,Yvonne Summers,Raffaele Califano,P. Taylor,Rajesh Shah,Piotr Krysiak,Kendadai Rammohan,Eustace Fontaine,Richard Booton,Matthew Evison,Philip Crosbie,Stuart Moss,Faiza Idries,Leena Joseph,Paul Bishop,Anshuman Chaturved,Anne Quinn,Helen Doran,Angela Leek,Phil Harrison,Katrina Moore,Rachael Waddington,Juliette Novasio,Fiona Blackhall,Jane Rogan,Elaine Smith,Caroline Dive,Jonathan Tugwood,Ged Brady,Dominic Rothwell,Francesca Chemi,Jackie Pierce,Sakshi Gulati,Babu Naidu,Gerald Langman,Simon Trotter,Mary Bellamy,Hollie Bancroft,Amy Kerr,Salma Kadiri,Joanne Webb,Gary Middleton,Madava Djearaman,Dean Fennell,Jacqui Shaw,John Quesne,David Moore,Apostolos Nakas,Sridhar Rathinam,William Monteiro,Hilary Marshall,Louise Nelson,Jonathan Bennett,Joan Riley,Lindsay Primrose,Luke Martinson,Girija Anand,Sajid Khan,Anita Amadi,M. Nicolson,Keith Kerr,Shirley Palmer,Hardy Remmen,J. Miller,Keith Buchan,Mahendran Chetty,Lesley Gomersall,J.F. Lester,Alison Edwards,Fiona Morgan,Haydn Adams,Helen Davies,Malgorzata Kornaszewska,Richard Attanoos,Sara Lock,Azmina Verjee,Mairead MacKenzie,Maggie Wilcox,Harriet Bell,Natasha Iles,Allan Hackshaw,Yenting Ngai,Sean Smith,Nicole Gower,Christian Ottensmeier,Serena Chee,Benjamin Johnson,Aiman Alzetani,Emily Shaw,Eric Lim,Paulo Sousa,Monica Barbosa,Alex Bowman,Simon Jorda,Alexandra Rice,Hilgardt Raubenheimer,Chiara Proli,Maria Cufari,John Ronquillo,Angela Kwayie,Harshil Bhayani,Morag Hamilton,Yusura Bakar,Natalie Mensah,Lyn Ambrose,Anand Devaraj,Silviu Buderi,Jonathan Finch,Leire Azcarate,Hema Chavan,Sophie Green,Hillaria Mashinga,Andrew Nicholson,Kelvin Lau,Michael Sheaff,Peter Schmid,John Conibear,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Peter Russell,Teresa Light,Tracey Horey,Sarah Danson,Jonathan Bury,John Edwards,Jennifer Hill,Sue Matthews,Yota Kitsanta,Kim Suvarna,Patricia Fisher,Allah Keerio,Michael Shackcloth,John Gosney,Pieter Postmus,Sarah Feeney,Julius Asante-Siaw,Martin Pulé