Paper
0
Characterization of HPV and host genome interactions in primary head and neck cancers
Authors
Michael Parfenov,Chandra Pedamallu
Nils Gehlenborg,Samuel Freeman,Ludmila Danilova,Christopher Bristow,Semin Lee,Angela Hadjipanayis,Elena Ivanova,Matthew Wilkerson,Alexei Protopopov,Lixing Yang,Sahil Seth,Xingzhi Song,Jiabin Tang,Xiaojia Ren,Jianhua Zhang,Angeliki Pantazi,Netty Santoso,Andrew Xu,Harshad Mahadeshwar,David Wheeler,Robert Haddad,Joonil Jung,Akinyemi Ojesina,Natalia Issaeva,Wendell Yarbrough,D. Hayes,Jennifer Grandis,Adel El‐Naggar,Matthew Meyerson,Peter Park,Lynda Chin,Jonathan Seidman,Peter Hammerman,Raju Kucherlapati,Adrian Ally,Miruna Balasundaram,İnanç Birol,Reanne Bowlby,Yaron Butterfield,Rebecca Carlsen,Dean Cheng,Andy Chu,Noreen Dhalla,Ranabir Guin,Robert Holt,Steven Jones,Darlene Lee,Haiyan Li,Marco Marra,Michael Mayo,Richard Moore,Andrew Mungall,A. Robertson,Jacqueline Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Tina Wong,Psalm Haseley,Dong Zeng,Rehan Akbani,Tod Casasent,Wenbin Liu,Yiling Lu,Gordon Mills,Thomas Motter,John Weinstein,Lixia Diao,Jing Wang,You Fan,Jinze Liu,Kai Wang,J. Auman,Saianand Balu,Tom Bodenheimer,Elizabeth Buda,Katherine Hoadley,Alan Hoyle,Joshua Stuart,Corbin Jones,Patrick Kimes,J. Marron,Shaowu Meng,Piotr Mieczkowski,Lisle Mose,Charles Perou,Jan Prins,Jeffrey Roach,Yan Shi,Janae Simons,Darshan Singh,Mathew Soloway,Donghui Tan,Umadevi Veluvolu,Vonn Walter,Stephen Waring,Junyuan Wu,Ni Zhao,Andrew Cherniack,Aaron Tward,Gordon Saksena,Scott Carter,Travis Zack,Steven Schumacher,Rameen Beroukhim,Juok Cho,Gad Getz,Michael Noble,Daniel DiCara,Hailei Zhang,David Heiman,Doug Voet,Pei Lin,Scott Frazer,Petar Stojanov,Yingchun Liu,Lihua Zou,Jaegil Kim,Michael Lawrence,Carrie Sougnez,Lee Lichtenstein,Kristian Cibulskis,Eric Lander,Stacey Gabriel,Donna Muzny,HarshaVardhan Doddapaneni,Christie Kovar,Jeff Reid,Donna Morton,Yi Han,Walker Hale,Hsu Chao,Kyle Chang,Jennifer Drummond,Richard Gibbs,Nipun Kakkar,Xi Liu,Giovanni Ciriello,Marc Ladanyi,William Lee,Ricardo Ramirez,Chris Sander,Ronglai Shen,Rileen Sinha,Nils Weinhold,Barry Taylor,Bülent Aksoy,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Skanderup,Boris Reva,Nikolaus Schultz,S. Sumer,Yichao Sun,Timothy Chan,Luc Morris,Stephen Benz,Sam Ng,Christopher Benz,Christina Yau,Stephen Baylin,Leslie Cope,James Herman,Moiz Bootwalla,Dennis Maglinte,Peter Laird,Timothy Triche,Daniel Weisenberger,David Berg,Nishant Agrawal,Justin Bishop,Paul Boutros,Jeff Bruce,Kai Ye,Joseph Califano,Thomas Carey,Zhong Chen,Hui Cheng,Simion Chiosea,Ezra Cohen,Brenda Diergaarde,Ann Egloff,Robert Ferris,Mitchell Frederick,Yan Guo,Thomas Harris,Angela Hui,J. Lee,Scott Lippman,Fei‐Fei Liu,Jonathan McHugh,Jeff Myers,Patrick Ng,Bayardo Perez-Ordóñez,Curtis Pickering,Michael Prystowsky,Marjorie Romkes,Anthony Saleh,Maureen Sartor,Raja Seethala,Tanguy Seiwert,Han Si,Carter Waes,Daryl Waggott,Maciej Wiznerowicz,Jiexin Zhang,Zhixiang Zuo,Ken Burnett,Daniel Crain,Johanna Gardner,Kevin Lau,David Mallery,Scott Morris,Joseph Paulauskis,Robert Penny,Candance Shelton,Troy Shelton,Mark Sherman,Peggy Yena,Aaron Black,Jay Bowen,Jessica Frick,Julie Gastier‐Foster,Hollie Harper,Tara Lichtenberg,Nilsa Ramirez,Lisa Wise,Erik Zmuda,Julien Baboud,Mark Jensen,A Kahn,Todd Pihl,David Pot,Deepak Srinivasan,Jessica Walton,Yunhu Wan,Robert Burton,Tanja Davidsen,John Demchok,Greg Eley,Martin Ferguson,Kenna Shaw,Bradley Ozenberger,Margi Sheth,Heidi Sofia,Roy Tarnuzzer,Linghua Wang,Liming Yang,Jean Zenklusen,Charles Saller,Katherine Tarvin,Chu Chen,Roni Bollag,Paul Weinberger,Wojciech Golusiński,Paweł Golusiński,Matthiew Ibbs,Konstanty Korski,Andrzej Maćkiewicz,Wiktoria Suchorska,Bartosz Szybiak,Erin Curley,Christina Beard,Colleen Mitchell,George Sandusky,Julie Ahn,Zubair Khan,Jonathan Irish,John Waldron,Sophie Egea,Carmen Gomez‐Fernandez,Lynn Herbert,Carol Bradford,Douglas Chepeha,Tamara Jones,Christine Komarck,Mayya Malakh,Jeffrey Moyer,Ariane Nguyen,Lisa Peterson,Mark Prince,Laura Rozek,Evan Taylor,Heather Walline,Gregory Wolf,Lori Boice,Bhishamjit Chera,William Funkhouser,Margaret Gulley,Trevor Hackman,Michele Hayward,Mei Huang,W. Rathmell,Ashley Salazar,W. Shockley,Carol Shores,Leigh Thorne,Mark Weissler,S. Wrenn,Adam Zanation,Brandee Brown,Michelle Pham
+303 authors
,Anna CasasentPublished
Oct 13, 2014
Show more
Save
Tip0
TipSave
Abstract
Significance A significant proportion of head and neck cancer is driven by human papillomavirus (HPV) infection, and the expression of viral oncogenes is involved in the development of these tumors. However, the role of HPV integration in primary tumors beyond increasing the expression of viral oncoproteins is not understood. Here, we describe how HPV integration impacts the host genome by amplification of oncogenes and disruption of tumor suppressors as well as driving inter- and intrachromosomal rearrangements. Tumors that do and do not have HPV integrants display distinct gene expression profiles and DNA methylation patterns, which further support the view that the mechanisms by which tumors with integrated and nonintegrated HPV arise are distinct.
Paper PDF
This paper's license is marked as closed access or non-commercial and cannot be viewed on ResearchHub. Visit the paper's external site.