T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia
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Authors
Armen Mardiros
Armen Mardiros•Cédric Santos•Stephen Forman
Published
September 13, 2013
Abstract
Key Points CD123 CAR T cells specifically target CD123+ AML cells. AML patient-derived T cells can be genetically modified to lyse autologous tumor cells.
