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Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Authors
Nicola Barban,Rick Jansen
Ronald Vlaming,Ahmad Vaez,Jornt Mandemakers,Felix Tropf,Xia Shen,James Wilson,Daniel Chasman,Ilja Nolte,Vinicius Tragante,Sander Laan,John Perry,Augustine Kong,Tarunveer Ahluwalia,Eva Albrecht,Laura Yerges-Armstrong,Gil Atzmon,Kirsi Auro,Kristin Ayers,Andrew Bakshi,Danny Ben‐Avraham,Kenneth Berger,Aviv Bergman,Lars Bertram,Lawrence Bielak,Gyða Björnsdóttir,Marc Bonder,Linda Broer,Minh Bui,Caterina Barbieri,Alana Cavadino,Jorge Chavarro,Constance Turman,Maria Concas,Heather Cordell,Gail Davies,Peter Eibich,Nicholas Eriksson,Tõnu Esko,Joel Eriksson,Fahimeh Falahi,Janine Felix,Mark Fontana,Lude Franke,Ilaria Gandin,Audrey Gaskins,Christian Gieger,Erica Gunderson,Xiuqing Guo,Caroline Hayward,Chunyan He,Edith Hofer,Hongyan Huang,Peter Joshi,Stavroula Kanoni,Robert Karlsson,Stefan Kiechl,Annette Kifley,Alexander Kluttig,Peter Kraft,Vasiliki Lagou,Cécile Lecœur,Jari Lahti,Ruifang Li‐Gao,Penelope Lind,Tian Liu,Enes Makalic,Crysovalanto Mamasoula,Lindsay Matteson,Hamdi Mbarek,Patrick McArdle,George McMahon,S. Meddens,Evelin Mihailov,Mike Miller,Stacey Missmer,Claire Monnereau,Peter Most,Ronny Myhre,Mike Nalls,Teresa Nutile,Ioanna Kalafati,Eleonora Porcu,Inga Prokopenko,Kumar Rajan,Janet Rich‐Edwards,Cornelius Rietveld,Antonietta Robino,Lynda Rose,Rico Rueedi,Kathleen Ryan,Yasaman Saba,Daniel Schmidt,Jennifer Smith,Lisette Stolk,Elizabeth Streeten,Anke Tönjes,Guðmar Þorleifsson,Sheila Ulivi,Juho Wedenoja,Juergen Wellmann,Peter Willeit,Jie Yao,Loïc Yengo,Wei Zhao,Daria Zhernakova,Najaf Amin,Howard Andrews,Beverley Balkau,Nir Barzilai,Sven Bergmann,Ginevra Biino,Hans Bisgaard,Klaus Bønnelykke,Dorret Boomsma,Julie Buring,Harry Campbell,Stefania Cappellani,Marina Ciullo,Simon Cox,Francesco Cucca,Daniela Toniolo,George Smith,Ian Deary,George Dedoussis,Panos Deloukas,Cornelia Duijn,Eco Geus,Johan Eriksson,Denis Evans,Jessica Faul,Cinzia Sala,Philippe Froguel,Paolo Gasparini,Giorgia Girotto,Hans Grabe,Karin Greiser,Patrick Groenen,Hugoline Haan,Johannes Haerting,Tamara Harris,Andrew Heath,Kauko Heikkilä,Albert Hofman,Georg Homuth,Elizabeth Holliday,John Hopper,Elina Hyppönen,Bo Jacobsson,Vincent Jaddoe,Magnus Johannesson,Astanand Jugessur,Mika Kähönen,Eero Kajantie,Sharon Kardia,Bernard Keavney,Ivana Kolčić,Päivikki Koponen,Péter Kovács,Florian Kronenberg,Zoltán Kutalik,Martina Bianca,Geneviève Lachance,William Iacono,Sandra Lai,Terho Lehtimäki,David Liewald,Cecilia Lindgren,Yongmei Liu,Robert Luben,Michael Lucht,Riitta Luoto,Per Magnus,Patrik Magnusson,Nicholas Martin,Matt McGue,Ruth McQuillan,Sarah Medland,Christa Meisinger,Dan Mellström,Andres Metspalu,Michela Traglia,Lili Milani,Paul Mitchell,Grant Montgomery,Dennis Mook‐Kanamori,Renée Mutsert,Ellen Nøhr,Claes Ohlsson,Jørn Olsen,Ken Ong,Lavinia Paternoster,Alison Pattie,Brenda Penninx,Markus Perola,Patricia Peyser,Mario Pirastu,Ozren Polašek,Chris Power,Jaakko Kaprio,Leslie Raffel,Katri Räikkönen,Olli Raitakari,Paul Ridker,Susan Ring,Kathryn Roll,Igor Rudan,Daniela Ruggiero,Dan Rujescu,Veikko Salomaa,David Schlessinger,Helena Schmidt,Reinhold Schmidt,Nicole Schupf,Johannes Smit,Rossella Sorice,Tim Spector,John Starr,Doris Stöckl,Konstantin Strauch,Michael Stümvoll,Morris Swertz,Unnur Þorsteinsdóttir,Roy Thurik,Nicholas Timpson,Joyce Tung,André Uitterlinden,Simona Vaccargiu,Jorma Viikari,Véronique Vitart,Henry Völzke,Péter Vollenweider,Dragana Vuckovic,Johannes Waage,Gert Wagner,Jie Wang,Nicholas Wareham,David Weir,Gonneke Willemsen,Johann Willeit,Alan Wright,Krina Zondervan,Kári Stéfansson,Robert Krueger,James Lee,Daniel Benjamin,David Cesarini,Philipp Koellinger,Marcel Hoed,Harold Snieder,Melinda Mills,Ritsert Jansen,Laura Yerges‐Armstrong
+252 authors
,Dan ArkingJournal
Published
Oct 31, 2016
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Abstract
The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
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