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Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
Authors
Phuwanat Sakornsakolpat,Dmitry Prokopenko
Maxime Lamontagne,Nicola Reeve,Anna Guyatt,Victoria Jackson,Nick Shrine,Dandi Qiao,Traci Bartz,Deog Kim,Mi Lee,Jeanne Latourelle,Xingnan Li,Jarrett Morrow,Ma’en Obeidat,Annah Wyss,Per Bakke,R. Barr,Terri Beaty,Steven Belinsky,Guy Brusselle,James Crapo,Kim Jong,Dawn DeMeo,Tasha Fingerlin,Sina Gharib,Amund Gulsvik,Ian Hall,John Hokanson,Woo Kim,David Lomas,Stephanie London,Deborah Meyers,George O'connor,Stephen Rennard,David Schwartz,Paweł Śliwiński,David Sparrow,David Strachan,Ruth Tal‐Singer,Yohannes Tesfaigzi,Jørgen Vestbo,Judith Vonk,Jae‐Joon Yim,Xiaobo Zhou,Yohan Bossé,Ani Manichaikul,Lies Lahousse,Edwin Silverman,H. Boezen,Louise Wain,Martin Tobin,Brian Hobbs,Michael Cho,Chiara Batini,Jing Zhao,Matthias Wielscher,Stefan Weiß,Katherine Kentistou,James Cook,Jennie Hui,Stefan Karrasch,Medea Imboden,Sarah Harris,Jonathan Marten,Stefan Enroth,Shona Kerr,Ida Surakka,Véronique Vitart,Terho Lehtimäki,Ralf Ewert,Christian Gieger,Georg Homuth,Peter Joshi,Claudia Langenberg,Lars Lind,Jian’an Luan,Anubha Mahajan,Alison Murray,David Porteous,Rajesh Rawal,Blair Smith,Paul Timmers,Olli Raitakari,Mika Kähönen,Ozren Polašek,Ulf Gyllensten,Igor Rudan,Ian Deary,Nicole Probst‐Hensch,Holger Schulz,Anthony James,James Wilson,Beate Stubbe,Eleftheria Zeggini,Marjo‐Riitta Järvelin,Nicholas Wareham,Caroline Hayward,Andrew Morris,Àlvar Agustí,Wayne Anderson,Nawar Bakerly,Robert Bals,Kathleen Barnes,Eugene Bleecker,Russell Bowler,Christopher Brightling,Marleen Bruijne,Peter Castaldi,Bartolomé Celli,Harvey Coxson,Ron Crystal,Pim Jong,Asger Dirksen,Jennifer Dy,Marilyn Foreman,Judith Garcia‐Aymerich,Pierre Gevenois,Soumitra Ghosh,Hester Gietema,Nadia Hansel,Craig Hersh,Eric Hoffman,Noor Kalsheker,Hans‐Ulrich Kauczor,Tarja Laitinen,Diether Lambrechts,Sang‐Do Lee,Augusto Litonjua,Daan Loth,Sharon Lutz,David Lynch,William MacNee,Merry‐Lynn McDonald,John Newell,Børge Nordestgaard,Yeon‐Mok Oh,Peter Paré,Massimo Pistolesi,Dirkje Postma,Milo Puhan,Elizabeth Regan,Stephen Rich,Joon Seo,A. Short,Berend Stoel,Nicola Sverzellati,Gerben Riet,Edwin Beek,Bram Ginneken,Claus Vogelmeier,Adam Wanner,George Washko,Els Wauters,Emiel Wouters,Robert Young,Loems Zeigler-Heitbrock,Alan Wright
+156 authors
,Alan JamesJournal
Published
Feb 25, 2019
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Abstract
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P < 5 × 10
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