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Genetic loci influencing kidney function and chronic kidney disease
Authors
John Chambers,Weihua Zhang
Graham Lord,Pim Harst,Debbie Lawlor,Joban Sehmi,Daniel Gale,Mark Wass,Kourosh Ahmadi,Stephan Bakker,J. Beckmann,Henk Bilo,Murielle Bochud,Matthew Brown,Mark Caulfield,John Connell,H. Cook,Ioana Cotlarciuc,George Smith,Ranil Silva,Guohong Deng,Olivier Devuyst,L.D. Dikkeschei,Nada Dimković,Mark Dockrell,Anna Dominiczak,Shah Ebrahim,Thomas Eggermann,Martin Farrall,Luigi Ferrucci,Jürgen Floege,Nita Forouhi,Ron Gansevoort,Xijin Han,Bo Hedblad,Jaap Heide,Bouke Hepkema,María Hernández-Fuentes,Elina Hyppönen,Toby Johnson,Paul Jong,Nanne Kleefstra,Vasiliki Lagou,Marta Lapsley,Yun Li,Ruth Loos,Jian’an Luan,Karin Luttropp,Céline Maréchal,Olle Melander,Patricia Munroe,Louise Nordfors,Afshin Parsa,Leena Peltonen,Brenda Penninx,Esperanza Perucha,Anneli Pouta,Inga Prokopenko,Paul Roderick,Aimo Ruokonen,Nilesh Samani,Serena Sanna,Martin Schalling,David Schlessinger,Georg Schlieper,Marc Seelen,Alan Shuldiner,Marketa Sjögren,Johannes Smit,Harold Snieder,Nicole Soranzo,Timothy Spector,Peter Stenvinkel,Michael Sternberg,R. Swaminathan,Toshiko Tanaka,L.J. Ubink-Veltmaat,Manuela Uda,Péter Vollenweider,Chris Wallace,Dawn Waterworth,Klaus Zerres,Gérard Waeber,Nicholas Wareham,Patrick Maxwell,Mark McCarthy,Marjo‐Riitta Järvelin,Vincent Mooser,Goncalo Abeçasis,Liz Lightstone,Berthold Lausen,Gerjan Navis,Paul Elliott,Jaspal Kooner,Jacques Beckmann,Paramit Chowdhury
+94 authors
,Gonçalo AbecasisJournal
Published
Apr 11, 2010
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Abstract
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
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