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Minimally instrumented SHERLOCK (miSHERLOCK) for CRISPR-based point-of-care diagnosis of SARS-CoV-2 and emerging variants

Molecular Biology

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Authors

Helena Puig,Rose Lee

Devora Najjar,Xiao Tan,Luis Soenksen,Nicolaas Angenent-Mari,Nina Donghia,Nicole Weckman,Audrey Ory,Carlos Ng,Peter Nguyen,Angelo Mao,Thomas Ferrante,Geoffrey Lansberry,Hani Sallum,James Niemi

+14 authors

Journal

Science Advances

Published

Aug 6, 2021

DOI

10.1126/sciadv.abh2944

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Abstract

An integrated, low-cost, sample-to-answer, CRISPR-based diagnostic detects SARS-CoV-2 and variants from unprocessed saliva.

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