Objective Patient‐reported outcome measures (PROMs), which capture patients' perspectives on the consequences of health and disease, are widely used in neurological care and research. However, it is unclear how PROMs relate to performance‐rated impairments. Sociodemographic factors are known to affect PROMs. Direct damage to brain regions critical for self‐awareness (i.e., parietal regions and the salience/ventral‐attention network) may also impair self‐report outcomes. This study examined the relationship between PROMs and performance‐based measures in stroke survivors with arm motor impairments. We hypothesized that PROMs would be distinct from performance‐based outcomes, influenced by sociodemographic factors, and linked to damage in brain circuits involved in self‐perception. Methods We longitudinally assessed 54 stroke survivors using patient‐reported and performance‐rated measures at 4 timepoints. We used factor analysis to reveal the outcome battery's factorial structure. Linear regression examined the association between classes of measures and sociodemographics. Voxel‐lesion‐symptom‐mapping, region‐of‐interest‐based analysis, and voxel‐lesion‐network‐mapping investigated the relationship between classes of outcomes and stroke‐related injury. Results Performance‐based and patient‐reported measures formed distinct factors, consistent across recovery phases. Higher education (β1 = 0.36, p = 0.02) and income adequacy (β2 = 0.48, p = 0.05) were associated with patient‐reported, but not performance‐rated outcomes. Greater parietal lobe injury, irrespective of hemisphere, was associated with worse patient‐reported outcomes; greater corticospinal tract injury related to worse performance‐rated outcomes. Lesions with greater functional connectivity to the salience/ventral‐attention network were associated with worse patient‐reported outcomes ( r = −0.35, p = 0.009). Interpretation Our findings reveal important differences between performance‐rated and patient‐reported outcomes, each with specific associated factors and anatomy post‐stroke. Incorporating sociodemographic and neuroanatomic characteristics into neurorehabilitation strategies may inform and optimize patient outcomes. ANN NEUROL 2024

Distinct Constructs Underlie Patient‐Reported and Performance‐Rated Outcomes after Stroke