Active‐Matrix Metalloproteinase‐8, Myeloperoxidase in Relation With Periodontics, Preterm Birth

Abstract

ABSTRACT Objective To investigate serum, placental levels of active‐matrix metalloproteinase‐8 (aMMP‐8), myeloperoxidase (MPO) in preterm‐birth with/without pre‐eclampsia and term counterparts in relation with clinical periodontal parameters. Methods Clinical periodontal measurements were recorded. Serum and placenta samples were collected during 173 full‐term (FT), pre‐term (PT) or pre‐term complicated by pre‐eclampsia (PTPE) deliveries. aMMP‐8 levels were measured by IFMA. MPO levels in the serum and placenta samples were determined by ELISA. Data were tested using non‐parametric tests. Results PTBE group exhibited higher full‐mouth probing depth and clinical attachment loss values than the other two groups ( p < 0.05). Percentages of sites with plaque and bleeding on probing were lower in the PTBE group than in the other groups ( p < 0.05). Serum aMMP‐8 and MPO concentrations were higher in PTPE group than in the other groups ( p < 0.05). Placenta aMMP‐8 level was higher in the control group than in the PTPE group ( p < 0.05). There was no significant difference between the groups in the placenta MPO levels ( p > 0.05). Conclusions Within the limits of this cross‐sectional study, it may be suggested that serum aMMP‐8 and MPO concentrations together with placenta aMMP‐8 levels may be associated with and reflect adverse pregnancy outcomes. Clinical periodontal findings did not reveal significant associations with these proteolytic and oxidative biomarkers.