A single upstream mutation of whiB7 underlies amikacin and clarithromycin resistance in Mycobacterium abscessus

Abstract

We aimed to investigate the molecular mechanisms underlying the survival of Mycobacterium abscessus when faced with antibiotic combination therapy. By conducting evolution experiments and whole genome sequencing (WGS), we sought to identify genetic variants associated with stress response mechanisms, with a particular focus on drug survival and resistance.