Abstract

Motivation: This study aims to contribute novel insights into the potential cognitive role of myo-inositol and its implications for brain metabolism using 7 Tesla magnetic resonance spectroscopy (7T-MRS). Goal(s): Our primary goal was to determine if myo-inositol concentrations within the posterior cingulate cortex (PCC) influence cognitive performance. Approach: Ultra-high field 7T-MRS was used to measure myo-inositol concentrations in relation to cognitive performance, as assessed with the Trail-Making-Test (TMT-A/B). Data analysis involved multiple linear regressions with covariate control and bootstrapping for robustness. Results: Our study reveals a significant (p<0.05) positive association between higher myo-inositol levels in the PCC and enhanced cognitive performance in TMT-A/B. Impact: This study suggests the potential of myo-inositol as a biomarker for cognitive functioning. Furthermore, the findings contribute to our understanding of brain neurochemistry, supporting the advancement of personalised medicine for cognitive impairments.