Abstract

Motivation: A previous own study in healthy volunteers indicated that global laminar connectivity is highly dynamic, suggesting that it could be sensitive to altered brain conditions. Goal(s): Does global laminar connectivity change in depression? Approach: We acquired high-resolution fMRI data from patients before and after treatment and conducted a dynamic connectivity analysis focused on cortical depth. Results: The prevalence of the depth-connectivity states co-evolved with the psychometric scores of patients. Impact: The presented results may motivate other researchers working on laminar fMRI to average across ROIs and evaluate the effect of diverse brain conditions on the global component of depth-dependent connectivity, whose potential relevance is suggested by our preliminary studies.