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Applications of covalent chemistry in targeted protein degradation

Molecular Biology

Organic Chemistry

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Authors

Hanfeng Lin,Ran Cheng,Erika Monroy,Xiaoli Qi,Meng Wang

+5 authors

Journal

Chemical Society Reviews

Published

Jan 1, 2022

DOI

10.1039/d2cs00362g

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Abstract

This review summarizes the recent work of covalent chemistry in targeted protein degradation and describes the concept, pros and cons, development, and the outlook of covalent PROTACs.

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