Altered Interactive Dynamics of Neurofluids in Cerebral Small Vessel Disease

Abstract

Motivation: While changes of neurofluid dynamic has been observed in CSVD, the potential inter-correlations between them are still unclear. Goal(s): Our goal was to demonstrate the potential interactive dynamics of neurofluids including the parenchyma perfusion, the glymphatic pathway, and the intracranial CSF in CSVD patients. Approach: Parenchyma perfusion was assessed with pASL, glymphatic dynamics was assessed with DTI- ALPS, and CSF volume of ventricles was also quantified. Results: The interactive dynamics of neurofluids of CSVD patients is significantly altered compared with that of normal elderly. Impact: Disruption of neurofluid dynamics may play an important role in the pathophysiology of CSVD.