Abstract

Motivation: Nuisance signal contamination and challenges associated with implementation involving advanced RF pulses and sequence hinder clinical adoption. Simplified sequence implementation and dissemination are crucial for community-driven advancement and vendor support. Goal(s): Our goal is to integrate CHEmical-shift selective Adiabatic refocusing Pulses(CHEAP) on the Philips platform via Pulseq open-source platform, creating advanced MRSI sequences that refine metabolite analysis by minimizing unwanted signals. Approach: Integrating chemically selective adiabatic 2-refocus pulses in Pulseq achieved optimal spectrum coverage, reducing interference from residual water and lipid signals. Results: Implementing the CHEAP sequence significantly mitigated interference from residual water and lipid signals, demonstrating its potential for advancing MRSI. Impact: The implementation of CHEAP sequence via Pulseq promises a standardized, shareable method, fostering collaboration and enabling precise metabolic studies. This advancement in MRS techniques may significantly improve reproducibility across sites and enhance capacity for metabolic profiling in health and disease.