White matter alterations in brain fog: A Long-Covid study

Abstract

Motivation: The symptoms of brain fog include problems with concentration, memory, attention, which result in difficulties with communication. This can make it extremely difficult for an individual to carry out daily tasks and responsibilities as well as maintain relationships deteriorating their quality of life. Goal(s): To investigate white matter alteration in Long-COVID. Approach: Voxel-wise analysis of core white matter voxels using advanced MRI metrics and neuropsychological scores. Results: Results highlight promising perspective for further investigations and potential clinical interpretation of Long-COVID syndromesImpact: The addition of MRI enables a more thorough exploration of the diverse cognitive dimensions affected in individuals experiencing brain fog and perhaps the possibility to understanding the involvement of WM alterations as either a risk factor or consequence of Long-COVID.