Abstract

Motivation: Impaired brain energy metabolism at early stage is found to be the driving factor of Alzheimer’s Disease (AD) progression. Goal(s): The study aim to investigate the potential of using deuterium magnetic resonance imaging to characterize the glucose metabolism in AD mouse model. Approach: Deuterium magnetic resonance spectroscopic imaging with the administration of [2,3,4,6,6’-2H5]-D-Glucose in 5xFAD and C57 mice. Results: Our preliminary results indicate higher glutamine/glutamate (Glx) production rate in 5xFAD mice compared to normal mice, especially in the hypothalamus region. Impact: Our work may shed light on developing new method in the early detection of AD based on the glucose metabolism abnormality.