Abstract

Motivation: NORDIC denoising can effectively enhance the limited SNR in high-resolution fMRI. However, its application on VASO is yet to be validated. Goal(s): We aimed to evaluate applications of NORDIC on VASO data and to offer recommendations for its execution. Approach: We examined NORDIC’s capability to suppress noise while preserving the VASO signal across a wide parameter spectrum Results: With a proper set of parameters, NORDIC effectively suppressed noise with minimal biases on the underlying signal. Impact: NORDIC can substantially enhance the SNR in submillimeter VASO fMRI. We found the denoising performance to be sensitive to parameter choices and provide recommendations for safe execution.