ResearchHub Logo
Currency
Display format
RSCUSD

White Matter Microstructure Alterations and Their Link to Symptomatology in Early Psychosis and Schizophrenia

Authors
Tommaso PavanYasser Alemán‐GómezIleana Jelescu
Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
November 26, 2024

Abstract

Motivation: Schizophrenia features complex symptomatology. Increased dMRI measures specificity is the key to capture the relation of white matter microstructure alterations with patients psychopathology. Goal(s): We aim to better characterize WM pathology and, thus, understand its relation with the symptomatology of early-psychosis and schizophrenia. Approach: Diffusion Kurtosis Imaging and White Matter Tract Integrity–Watson were estimated in 275 individuals. Whole-brain WM estimates were compared between patients and controls, and associated with patients psychopathology. Results: dMRI patterns suggest that WM alterations are already present and widespread in EP. Two trends of WM deterioration with concomitant demyelination vs neuroinflammation were found associated with clinical scales regression analysis. Impact: Our findings possibly provide a missing link between specific symptoms and underlying pathology. The association between patients' psychopathology and advanced dMRI metrics may spark further interest in linking specific symptom in psychiatry diseases to microstructure alterations.

Supporters

Support the authors with ResearchCoin

Topics

DOI

10.58530/2024/5030

License

Unknown License
White Matter Microstructure Alterations and Their Link to... | ResearchHub