A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Li Li,Audrey Chu,Praveen Surendran,Robin Young,Niels Grarup,Alena Stančáková,Yuning Chen,Tibor Varga,Hanieh Yaghootkar,Jian’an Luan,Jing Zhao,Sara Willems,Jennifer Wessel,Shuai Wang,Nisa Maruthur,Kyriaki Michailidou,Ailith Pirie,Sven Lee,Christopher Gillson,Ali Olama,Philippe Amouyel,Larraitz Arriola,Dominique Arveiler,Icíar Avilés-Olmos,Beverley Balkau,Aurelio Barricarte,Inês Barroso,Sara Garcia,Joshua Bis,Stefan Blankenberg,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Ingrid Borecki,Jette Bork‐Jensen,S. Bowden,Carlos Caldas,Muriel Caslake,L. Cupples,Carlos Cruchaga,Jacek Czajkowski,Marcel Hoed,Janet Dunn,Helena Earl,Georg Ehret,Ele Ferrannini,Jean Ferrières,Thomas Foltynie,Ian Ford,Nita Forouhi,Francesco Gianfagna,Carlos González,Sara Grioni,Louise Hiller,Jan‐Håkan Jansson,Marit Jørgensen,J. Jukema,Rudolf Kaaks,Frank Kee,Nicola Kerrison,Timothy Key,Jukka Kontto,Zsofia Kote‐Jarai,Aldi Kraja,Kari Kuulasmaa,Johanna Kuusisto,Allan Linneberg,Chun‐Yu Liu,Gaëlle Marenne,Karen Mohlke,Andrew Morris,Kenneth Muir,Martina Müller‐Nurasyid,Patricia Munroe,Carmen Navarro,Sune Nielsen,Peter Nilsson,Børge Nordestgaard,Chris Packard,Domenico Palli,Salvatore Panico,Gina Peloso,Markus Perola,Annette Peters,Christopher Poole,J. Quirós,Olov Rolandsson,Carlotta Sacerdote,Veikko Salomaa,María‐José Sánchez,Naveed Sattar,Stephen Sharp,Rebecca Sims,Nadia Slimani,Jennifer Smith,Deborah Thompson,Stella Trompet,­Rosario ­Tumino,Daphne A,Yvonne Schouw,Jarmo Virtamo,Mark Walker,Klaudia Walter,Jean Abraham,Laufey Ámundadóttir,Adam Butterworth,Jennifer Aponte,Josée Dupuis,Douglas Easton,Rosalind Eeles,Jeanette Erdmann,Paul Franks,Timothy Frayling,Torben Hansen,Joanna Howson,Torben Jørgensen,Jaspal Kooner,Markku Laakso,Mark McCarthy,James Pankow,Oluf Pedersen,Elio Ríboli,Jerome Rotter,Danish Saleheen,Nilesh Samani,Heribert Schunkert,Péter Vollenweider,Stephen O’Rahilly,Panos Deloukas,John Danesh,Mark Goodarzi,Sekar Kathiresan,James Meigs,Margaret Ehm,Nicholas Wareham,Dawn Waterworth,Tibor V Varga