Abstract

Abstract Background Vaccination prevents seasonal influenza and its complications, particularly among high-risk populations. The COVID-19 pandemic has been reported to impact healthcare behaviors and vaccination patterns. This study aims to assess influenza vaccination coverage and changes in vaccination settings among Canadian adults from the 2018–2019 to the 2023–2024 seasons. Method We conducted a retrospective analysis of data from multiple cycles of the Seasonal Influenza Vaccination Coverage Survey (SIVCS). Vaccination coverage was examined across different seasons, stratified by population groups. Odds ratios (ORs) were calculated to compare vaccination likelihoods across seasons, with 2018–2019 serving as the reference. Chi-square tests were applied to determine whether there were significant differences in the place of vaccination since the pre-pandemic season. Results When comparing vaccine uptake before, during and after the COVID-19 pandemic, we observed a temporary coverage decline in 2021–2022 season (OR = 0.882, 95% CI = 0.787–0.988) compared to the pre-pandemic season in 2018–2019. By the 2022–2023 and 2023–2024 seasons, vaccination coverage returned to pre-pandemic levels. Coverage among adults aged 18–64 without chronic medical condition consistently remained lower than in other groups. The places of vaccination shifted markedly, with pharmacies becoming the predominant site, increasing from 35.4% in 2018–2019 to 57.4% in 2023–2024, while doctor’s offices saw a decline from 32.7 to 15.2% over the same period. Conclusion Our findings highlight the transient effect of the pandemic on flu vaccine uptake in Canada. The increasing use of pharmacies for vaccinations underscores the importance of accessible and convenient vaccination sites. Future efforts should focus on maintaining and improving vaccination coverage through diverse and adaptable vaccination settings.