Abstract

Abstract We have updated the catalogue of common and well‐documented ( CWD ) human leukocyte antigen ( HLA ) alleles to reflect current understanding of the prevalence of specific allele sequences. The original CWD catalogue designated 721 alleles at the HLA ‐A, ‐B, ‐C, ‐ DRB1 , ‐ DRB3 /4/5, ‐ DQA1 , ‐ DQB1 , and ‐ DPB1 loci in IMGT (IMmunoGeneTics)/ HLA Database release 2.15.0 as being CWD . The updated CWD catalogue designates 1122 alleles at the HLA ‐A, ‐B, ‐C, ‐ DRB1 , ‐ DRB3 /4/5, ‐ DQA1 , ‐ DQB1 , ‐ DPA1 and ‐ DPB1 loci as being CWD , and represents 14.3% of the HLA alleles in IMGT / HLA Database release 3.9.0. In particular, we identified 415 of these alleles as being ‘common’ (having known frequencies) and 707 as being ‘well‐documented’ on the basis of ~140,000 sequence‐based typing observations and available HLA haplotype data. Using these allele prevalence data, we have also assigned CWD status to specific G and P designations. We identified 147/151 G groups and 290/415 P groups as being CWD . The CWD catalogue will be updated on a regular basis moving forward, and will incorporate changes to the IMGT / HLA Database as well as empirical data from the histocompatibility and immunogenetics community. This version 2.0.0 of the CWD catalogue is available online at cwd.immunogenomics.org , and will be integrated into the Allele Frequencies Net Database, the IMGT / HLA Database and National Marrow Donor Program's bioinformatics web pages.