Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

Hufeng Zhou,Sheila Gaynor,Yaowu Liu,Han Chen,Ryan Sun,Rounak Dey,Donna Arnett,Stella Aslibekyan,Christie Ballantyne,Lawrence Bielak,John Blangero,Eric Boerwinkle,Donald Bowden,Jai Broome,Matthew Conomos,Adolfo Correa,L. Cupples,Joanne Curran,Barry Freedman,Xiuqing Guo,George Hindy,Marguerite Irvin,Sharon Kardia,Sekar Kathiresan,Alyna Khan,Charles Kooperberg,Cathy Laurie,X. Liu,Michael Mahaney,Ani Manichaikul,Lisa Martin,Rasika Mathias,Stephen McGarvey,Braxton Mitchell,May Montasser,Jill Moore,Alanna Morrison,Jeffrey O’Connell,Nicholette Palmer,Akhil Pampana,Juan Peralta,Patricia Peyser,Bruce Psaty,Susan Redline,Kenneth Rice,Stephen Rich,Jennifer Smith,Hemant Tiwari,Michael Tsai,Ramachandran Vasan,Fei Wang,Daniel Weeks,Zhiping Weng,James Wilson,Lisa Yanek,Namiko Abe,Gonçalo Abecasis,François Aguet,Christine Albert,Laura Almasy,Álvaro Alonso,Seth Ament,Peter Anderson,Pramod Anugu,Deborah Applebaum‐Bowden,Kristin Ardlie,Dan Arking,Allison Ashley‐Koch,Tim Assimes,Paul Auer,Dimitrios Avramopoulos,John Barnard,Kathleen Barnes,R. Barr,Emily Barron‐Casella,Lucas Barwick,Terri Beaty,Gerald Beck,Diane Becker,Lewis Becker,Rebecca Beer,Amber Beitelshees,Emelia Benjamin,Takis Benos,Marcos Bezerra,Joshua Bis,Thomas Blackwell,Russell Bowler,Jennifer Brody,Ulrich Broeckel,Karen Bunting,Esteban Burchard,Carlos Bustamante,Erin Buth,Brian Cade,Jonathan Cardwell,Vincent Carey,Cara Carty,Richard Casaburi,James Casella,Peter Castaldi,Mark Chaffin,Christy Chang,Yi‐Cheng Chang,Daniel Chasman,Sameer Chavan,Bo‐Juen Chen,Wei‐Min Chen,Yii‐Der Chen,Michael Cho,Seung Choi,Lee‐Ming Chuang,Mina Chung,Ren‐Hua Chung,Clary Clish,Suzy Comhair,Elaine Cornell,Carolyn Crandall,James Crapo,Jeffrey Curtis,Brian Custer,Coleen Damcott,Dawood Darbar,Sayantan Das,Sean David,Colleen Davis,Michelle Daya,Mariza Andrade,Lisa Fuentes,Michael DeBaun,Ranjan Deka,Dawn DeMeo,Scott Devine,Qing Duan,Ravi Duggirala,Jon Durda,Susan Dutcher,Charles Eaton,Lynette Ekunwe,Adel Boueiz,Patrick Ellinor,Leslie Emery,Serpil Erzurum,Charles Farber,Tasha Fingerlin,Matthew Flickinger,Myriam Fornage,Nora Franceschini,Chris Frazar,Mao Fu,Stephanie Fullerton,Lucinda Fulton,Stacey Gabriel,Weiniu Gan,Shanshan Gao,Yan Gao,Margery Gass,Bruce Gelb,Xiaoqi Geng,Mark Geraci,Søren Germer,Robert Gerszten,Auyon Ghosh,Richard Gibbs,Chris Gignoux,Mark Gladwin,David Glahn,Stephanie Gogarten,Da‐Wei Gong,Harald Göring,Sharon Graw,Daniel Grine,C. Gu,Yue Guan,Namrata Gupta,Jeff Haessler,Michael Hall,Daniel Harris,Nicola Hawley,Jiang He,Susan Heckbert,Ryan Hernandez,David Herrington,Craig Hersh,Bertha Hidalgo,James Hixson,Brian Hobbs,John Hokanson,Elliott Hong,Karin Hoth,Chao Hsiung,Yi‐Jen Hung,Haley Huston,Chii Hwu,Rebecca Jackson,Deepti Jain,Cashell Jaquish,Min Jhun,Jill Johnsen,Andrew Johnson,Craig Johnson,Rich Johnston,Kimberly Jones,Hyun Kang,Robert Kaplan,Shannon Kelly,Eimear Kenny,Michael Kessler,Wonji Kim,Gregory Kinney,Barbara Konkle,Holly Kramer,Christoph Lange,Ethan Lange,Leslie Lange,Cecelia Laurie,Meryl LeBoff,Jiwon Lee,Seunggeun Lee,Wen‐Jane Lee,Jonathon LeFaive,David Levine,Dan Levy,Joshua Lewis,Xiaohui Li,Yun Li,Henry Lin,Honghuang Lin,Keng Lin,Xihong Lin,Simin Liu,Yongmei Liu,Yu Liu,Ruth Loos,Steven Lubitz,Kathryn Lunetta,James Luo,Barry Make,JoAnn Manson,Lauren Margolin,Susan Mathai,Susanne May,Patrick McArdle,Merry‐Lynn McDonald,Sean McFarland,Daniel McGoldrick,Caitlin McHugh,Hao Mei,Luisa Mestroni,Deborah Meyers,Julie Mikulla,Yuan‐I Min,Mollie Minear,Ryan Minster,Matt Moll,Courtney Montgomery,Arden Moscati,Solomon Musani,Stanford Mwasongwe,Josyf Mychaleckyj,Girish Nadkarni,Rakhi Naik,Take Naseri,Pradeep Natarajan,Sergeï Nekhai,Sarah Nelson,Bonnie Neltner,Deborah Nickerson,Kari North,Tim O’Connor,Heather Ochs‐Balcom,David Paik,James Pankow,George Papanicolaou,Afshin Parsa,Marco Pérez,James Perry,Annette Peters,Lawrence Phillips,Toni Pollin,Wendy Post,Julia Becker,Meher Boorgula,Michael Preuß,Pankaj Qasba,Dandi Qiao,Zhaohui Qin,Nicholas Rafaels,Laura Raffield,D. Rao,Laura Rasmussen‐Torvik,Aakrosh Ratan,Robert Reed,Elizabeth Regan,Alex Reiner,Muagututi’a Reupena,Dan Roden,Carolina Roselli,Jerome Rotter,Ingo Ruczinski,Pamela Russell,Sarah Ruuska,Kathleen Ryan,Éster Sabino,Danish Saleheen,Shabnam Salimi,Steven Salzberg,Kevin Sandow,Vijay Sankaran,Christopher Scheller,Ellen Schmidt,Karen Schwander,David Schwartz,Frank Sciurba,Christine Seidman,Jonathan Seidman,Vivien Sheehan,Stephanie Sherman,Amol Shetty,Aniket Shetty,Wayne Sheu,M. Shoemaker,B. Silver,Edwin Silverman,J. Smith,Nicholas Smith,Tanja Smith,Sylvia Smoller,Beverly Snively,M Snyder,Tamar Sofer,Nona Sotoodehnia,Adrienne Stilp,Garrett Storm,Elizabeth Streeten,Jessica Lasky‐Su,Yan Sun,Jody Sylvia,Adam Szpiro,Carole Sztalryd,Daniel Taliun,Hua Tang,Margaret Taub,Kent Taylor,Matthew Taylor,Simeon Taylor,Marilyn Telen,Timothy Thornton,Machiko Threlkeld,Lesley Tinker,David Tirschwell,Sarah Tishkoff,Catherine Tong,Russell Tracy,Dhananjay Vaidya,David Berg,Peter VandeHaar,Scott Vrieze,Tarik Walker,Robert Wallace,Avram Walts,Heming Wang,Karol Watson,Bruce Weir,Scott Weiss,Lu‐Chen Weng,Jennifer Wessel,Cristen Willer,Kayleen Williams,L. Williams,Carla Wilson,Quenna Wong,Joseph Wu,Huichun Xu,Ivana Yang,Rongze Yang,Norann Zaghloul,Maryam Zekavat,Yingze Zhang,Snow Zhao,Wei Zhao,Degui Zhi,Xiang Zhou,Xiaofeng Zhu,Michael Zody,Sebastian Zoellner,Moustafa Abdalla,Elizabeth Atkinson,Corneliu Bodea,Jenna Carlson,I-Shou Chang,Sung Chun,Paul Vries,Ron Do,Amanda Elliott,Andrea Ganna,Sarah Graham,Mary Haas,Bernhard Haring,Blanca Himes,Gail Jarvik,Jicai Jiang,Goo Jun,Rita Kalyani,Amit Khera,Derek Klarin,B Král,Rozenn Lemaître,Ravi Mathur,John McLenithan,Andrew Moran,Tetsushi Nakao,Christopher O’Donnell,Aniruddh Patel,Gina Peloso,James Pirruccello,Samantha Rosenthal,Jenny Schoenberg,Margaret Selvaraj,Shamil Sunyaev,Ida Surakka,Md Uddin,Sarah Urbut,Marie Verbanck,Ann Holle,Kerri Wiggins,Brooke Wolford,Jingwen Zhang,Benjamin Neale