Secondary Sphere Interactions Modulate Peroxynitrite Scavenging by the E2 Domain of Amyloid Precursor Protein

Abstract

Peroxynitrite (ONOO − ) is a reactive nitrogen species causing cellular damage. The copper-binding E2 domain of amyloid precursor protein reduces ONOO − via single-electron transfer, highlighting its role in oxidative stress and Alzheimer's disease.