Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

He Zhang,Chenyi Xue,Ellen Schmidt,Zheng-Zheng Tang,Chris Bizon,Ethan Lange,Joshua Smith,Emily Turner,Goo Jun,Hyun Kang,Gina Peloso,Paul Auer,Kuo-ping Li,Jason Flannick,Ji Zhang,Christian Fuchsberger,Kyle Gaulton,Cecilia Lindgren,Adam Locke,Alisa Manning,Xueling Sim,Manuel Rivas,Oddgeir Holmen,Omri Gottesman,Yingchang Lu,Douglas Ruderfer,Eli Stahl,Qing Duan,Yun Li,Peter Durda,Shuo Jiao,Aaron Isaacs,Albert Hofman,Joshua Bis,Adolfo Correa,Michael Griswold,Jóhanna Jakobsdóttir,Albert Smith,Pamela Schreiner,Mary Feitosa,Qunyuan Zhang,Jennifer Huffman,Jacy Crosby,Christina Wassel,Ron Do,Nora Franceschini,Lisa Martin,Jennifer Robinson,Themistocles Assimes,David Crosslin,Elisabeth Rosenthal,Michael Tsai,Mark Rieder,Deborah Farlow,Aaron Folsom,Thomas Lumley,Ervin Fox,Christopher Carlson,Ulrike Peters,Rebecca Jackson,Cornelia Duijn,André Uitterlinden,Daniel Levy,Jerome Rotter,Herman Taylor,Vilmundur Guðnason,David Siscovick,Myriam Fornage,Ingrid Borecki,Caroline Hayward,Igor Rudan,Y. Chen,Erwin Böttinger,Ruth Loos,Pål Sætrom,Kristian Hveem,Michael Boehnke,Leif Groop,Mark McCarthy,Thomas Meitinger,Christie Ballantyne,Stacey Gabriel,Christopher O’Donnell,Wendy Post,Kari North,Alexander Reiner,Eric Boerwinkle,Bruce Psaty,David Altshuler,Sekar Kathiresan,Dan-Yu Lin,Gail Jarvik,L. Cupples,Charles Kooperberg,James Wilson,Deborah Nickerson,Gonçalo Abecasis,Stephen Rich,Russell Tracy,Cristen Willer,Hooman Allayee,Sharon Cresci,Mark Daly,Paul Bakker,Mark DePristo,Peter Donnelly,Tim Fennell,Kiran Garimella,Stanley Hazen,Daniel Jordan,Adam Kieżun,Guillaume Lettre,Bingshan Li,Mingyao Li,Christopher Newton‐Cheh,Sandosh Padmanabhan,Sara Pulit,Daniel Rader,David Reich,Muredach Reilly,Steven Schwartz,Laura Scott,John Spertus,Nathaniel Stitziel,Nina Stoletzki,Shamil Sunyaev,Benjamin Voight,Ermeg Akylbekova,Larry Atwood,Maja Barbalić,R. Barr,Emelia Benjamin,Donald Bowden,Jennifer Brody,Matthew Budoff,Greg Burke,Sarah Buxbaum,J. Carr,Donna Chen,Ida Chen,Wei‐Min Chen,Patrick Concannon,Ralph D’Agostino,Anita DeStefano,Albert Dreisbach,Josée Dupuis,Jon Durda,Jaclyn Ellis,Caroline Fox,Vincent Funari,Santhi Ganesh,Julius Gardin,David Goff,Ora Gordon,Wayne Grody,Myron Gross,Xiuqing Guo,Ira Hall,Nancy Heard‐Costa,Susan Heckbert,Nicholas Heintz,David Herrington,DeMarc Hickson,Jie Huang,Shih‐Jen Hwang,David Jacobs,Nancy Jenny,Andrew Johnson,Craig Johnson,Steven Kawut,Richard Kronmal,Raluca Kurz,Martin Larson,Mark Lawson,Cora Lewis,Dalin Li,Honghuang Lin,Chunyu Liu,Jiankang Liu,Kiang Liu,Xiaoming Liu,Yongmei Liu,W.T. Longstreth,Cay Loria,Kathryn Lunetta,Aaron Mackey,Rachel Mackey,Ani Manichaikul,Taylor Maxwell,Barbara McKnight,James Meigs,Alanna Morrison,Solomon Musani,Josyf Mychaleckyj,Jennifer Nettleton,Daniel O’Leary,Frank Ong,Walter Palmas,James Pankow,Nathan Pankratz,Shom Paul,Marco Pérez,Sharina Person,Joseph Polak,Aaron Quinlan,Leslie Raffel,Ramachandran Vasan,Kenneth Rice,Jill Sanders,Sudha Seshadri,Steve Shea,Stephen Sidney,Kevin Silverstein,Nicholas Smith,Nona Sotoodehnia,Asoke Srinivasan,Kent Taylor,Fridtjof Thomas,Kelly Volcik,Chrstina Wassel,Karol Watson,Gina Wei,Wendy White,Kerri Wiggins,Jemma Wilk,O. Williams,G. Wilson,Phillip Wolf,Neil Zakai,John Hardy,James Meschia,Michael Nalls,Andrew Singleton,Brad Worrall,Michael Bamshad,Kathleen Barnes,Ibrahim Abdulhamid,Frank Accurso,Ran Anbar,Terri Beaty,Abigail Bigham,Phillip Black,Eugene Bleecker,Kati Buckingham,Anne Cairns,Daniel Caplan,Barbara Chatfield,Aaron Chidekel,Michael Cho,David Christiani,James Crapo,Julia Crouch,Denise Daley,Anthony Dang,Hong Dang,Alicia Paula,Joan DeCelie‐Germana,Allen Drumm,Maynard Dyson,Julia Emerson,Mary Emond,Thomas Ferkol,Robert Fink,Cassandra Foster,Deborah Froh,Li Gao,William Gershan,Ronald Gibson,Elizabeth Godwin,Magdalen Gondor,Hector Gutiérrez,Nadia Hansel,Paul Hassoun,Peter Hiatt,John Hokanson,Michelle Howenstine,Laura Hummer,Jamshed Kanga,Yoonhee Kim,Michael Knowles,Michael Konstan,Thomas Lahiri,Nan Laird,Christoph Lange,Lin Lin,Xihong Lin,Tin Louie,David Lynch,Barry Make,Thomas Martin,Steve Mathai,Rasika Mathias,John McNamara,Sharon McNamara,Deborah Meyers,Susan Millard,Peter Mogayzel,Richard Moss,Tanda Murray,Dennis Nielson,Blakeslee Noyes,Wanda O’Neal,David Orenstein,Brian O’Sullivan,Rhonda Pace,Peter Paré,H. Parker,Mary Passero,Elizabeth Perkett,Adrienne Prestridge,Nicholas Rafaels,Bonnie Ramsey,Elizabeth Regan,Clement Ren,George Retsch‐Bogart,Michael Rock,Antony Rosen,Margaret Rosenfeld,Ingo Ruczinski,Andrew Sanford,David Schaeffer,Cindy Sell,Daniel Sheehan,Edwin Silverman,Don Sin,Terry Spencer,J. Stonebraker,Holly Tabor,Laurie Varlotta,Candelaria Vergara,Robert Weiss,Fred Wigley,Robert Wise,Fred Wright,Mark Wurfel,Robert Zanni,Fei Zou,Phil Green,Jay Shendure,Joshua Akey,Carlos Bustamante,Evan Eichler,Phillips Fox,Wenqing Fu,Allan Gordon,Simon Gravel,Jill Johnsen,Mengyuan Kan,Eimear Kenny,Jeffrey Kidd,Fremiet Lara-Garduno,Suzanne Leal,Dajiang Liu,Sean McGee,Timothy O’Connor,Bryan Paeper,Peggy Robertson,Jeffrey Staples,Jacob Tennessen,Gao Wang,Yi Qian,Annette Peters,Garnet Anderson,Hoda Anton‐Culver,Shirley Beresford,Henry Black,Robert Brunner,Robert Brzyski,Dale Burwen,Bette Caan,Cara Carty,Rowan Chlebowski,Steven Cummings,J. Curb,Charles Eaton,Leslie Ford,Stephanie Fullerton,Margery Gass,Nancy Geller,G. Heiss,Barbara Howard,Li Hsu,Carolyn Hutter,John Ioannidis,Karen Johnson,Lewis Kuller,Andrea LaCroix,Kamakshi Lakshminarayan,Dorothy Lane,Norman Lasser,Erin LeBlanc,Marian Limacher,Benjamin Logsdon,Shari Ludlam,JoAnn Manson,Karen Margolis,Joan McGowan,Keri Monda,Jane Kotchen,Lauren Nathan,Judith Ockene,Mary O’Sullivan,Lawrence Phillips,Ross Prentice,John Robbins,Jacques Rossouw,Haleh Sangi‐Haghpeykar,Gloria Sarto,Sally Shumaker,Michael Simon,Marcia Stefanick,Evan Stein,Hua Tang,Kira Taylor,Cynthia Thomson,Timothy Thornton,Linda Horn,Mara Vitolins,Jean Wactawski‐Wende,Robert Wallace,Sylvia Wassertheil‐Smoller,Donglin Zeng,Deborah Applebaum‐Bowden,Michael Feolo,Weiniu Gan,Dina Paltoo,Phyliss Sholinsky,Anne Sturcke,Vilmundur Gudnason