Abstract

Open AccessCCS ChemistryRESEARCH ARTICLES6 Dec 2024A Supramolecularly Activatable Photosensitizer: Controllable Cyanine J-aggregation for Efficient Photodynamic Therapy He Ma, Weiquan Xu, Xingchen Tang, Yushen Kang, Jiang-Fei Xu and Xi Zhang He Ma , Weiquan Xu , Xingchen Tang , Yushen Kang , Jiang-Fei Xu and Xi Zhang https://doi.org/10.31635/ccschem.024.202405042 SectionsSupplemental MaterialAboutPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked InEmail Activatable photosensitizer inducing phototoxicity only in target sites is highly demanded to overcome the potential off-target toxicity in photodynamic therapy. It is of great significance for designing tailored photosensitizers with new caging mechanism that can be activated by molecular signatures of pathogenic tissues. Herein, we report a novel supramolecularly activatable photosensitizer that employ cucurbit[7]uril (CB[7]) to regulate the J-aggregate and monomer state of a thio-pentamethine cyanine dye with α-naphthyl group on side arms (Naph-α-TCy5), switching its photosensitizing property between off-on states. The host-guest complex Naph-α-TCy5-CB[7] is a caged photosensitizer with superior luminescence property in aqueous solution. It can be effectively activated by polyamines in cancer cells through competitive host-guest complexation, and then the restored J-aggregates of Naph-α-TCy5 can efficiently generate singlet oxygen. Eventually, the supramolecularly activatable Naph-α-TCy5-CB[7] demonstrates appreciable antitumor bioactivity in vivo with excellent biosafety. It is anticipated that this design strategy of supramolecularly activatable photosensitizers opens new horizons for efficient photodynamic therapy with specificity and safety. Download figure Download PowerPoint Previous articleNext article FiguresReferencesRelatedDetails Issue AssignmentNot Yet AssignedSupporting Information Copyright & Permissions© 2024 Chinese Chemical Society Downloaded 0 times PDF downloadLoading ...