High-resolution antibody dynamics of vaccine-induced immune responses

Abstract

Significance The immune system must constantly adapt to combat infections and other challenges. This is accomplished by continuously evolving the antibody repertoire, and by maintaining memory of prior challenges. By using next-generation DNA sequencing technology, we have examined the shear amount of antibody made by individuals during a flu vaccination trial. We demonstrate one of the first characterizations of the fast antibody dynamics through time in multiple individuals responding to an immune challenge.