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Percutaneous closure of patent foramen ovale in migraine with aura, a randomized controlled trial

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Abstract

AimsMigraine with aura and patent foramen ovale (PFO) are associated. The Percutaneous Closure of PFO in Migraine with Aura (PRIMA) trial is a multicentre, randomized trial to investigate the effect of percutaneous PFO closure in patients refractory to medical treatment.

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