Percutaneous closure of patent foramen ovale in migraine with aura, a randomized controlled trial

Abstract

AimsMigraine with aura and patent foramen ovale (PFO) are associated. The Percutaneous Closure of PFO in Migraine with Aura (PRIMA) trial is a multicentre, randomized trial to investigate the effect of percutaneous PFO closure in patients refractory to medical treatment.