Abstract

The emergence of nano spray drying has revolutionized conventional spray drying by offering a simple and streamlined approach to obtaining ultrafine powders in the submicron and nanoscale range. Unlike traditional approaches, this innovative technology enables the direct conversion of solutions into dried nanoparticles, with high yields of up to 90%. The resulting particles exhibit a narrow size distribution, ranging from 300 nm to 5 μm, rendering them highly suitable for diverse drug delivery applications. Using characteristic features such as its piezoelectric atomizing technology and electrostatic particle collector, it encompasses the size spectrum of discrete particles down to the nano-scale with minimal product loss. The resultant nano spray dried powders can be administered via various routes, including oral, topical, ocular, nasal, and inhalation, offering improved drug delivery and enhanced therapeutic efficacy. This review explores the potential and applications of nano spray drying in pharmaceutical formulations, Highlighting its transformative impact on healthcare and its role in improving patient outcomes. However, several challenges need to be overcome before nano spray drying technology can be applied widely in the industry.