Aim: The aim of this study was to investigate and compare the antimicrobial effects of an 810-nanometer diode laser, utilizing or not utilizing toluidine blue as a photosensitizer, in the management of peri-implant mucositis. Settings and Design: The present study was carried out in 30 implant sites in 15 patients with peri-implant mucositis with a specific inclusion and exclusion criteria. 15 sites were treated utilizing a diode laser (control group) and 15 with photodynamic therapy (test group) in a split-mouth format. Materials and Methods: Samples were taken from the gingival sulcus with the help of plastic curettes from control and test sites both at baseline and at 3 months for microbiological analysis. Statistical Analysis Used: Shapiro-Wilk Test was used to check deviation from normality. Wilcoxon signed-rank test was used to analyse the two dependent groups. Results: Intragroup comparison was found to be statistically significant when compared at baseline and at 3 months in the photodynamic ( P = 0.001) and diode laser groups ( P = 0.001), respectively. No statistically significant reduction in bacterial count was found at baseline ( P = 0.1) and at 3 months ( P = 0.5) when the diode laser group and photodynamic group were compared with each other (intergroup). Conclusion: Within the limitations of the study, it can be concluded that there is a definitive reduction in pathogenic bacteria with both interventions and PDT offers clinically visible benefits in the treatment of peri-implant mucositis.
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