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Aberrant Complement Activation Is Associated With Structural Brain Damage in Multiple Sclerosis
Authors
Johanna Oechtering,Sabine Schädelin
Kerstin Stein,Aleksandra Maceski,Lester Melie‐García,Pascal Benkert,Alessandro Cagol,Selina Leber,Riccardo Galbusera,Esther Ruberte,Wayne Hu,Ferhan Qureshi,Annette Orleth,Lilian Demuth,Eline Willemse,Ingmar Heijnen,Axel Regeniter,Tobias Derfuß,Bettina Fischer‐Barnicol,Lutz Achtnichts,Stefanie Mueller,Robert Hoepner,Patrice Lalive,Claire Bridel,Marcus D’Souza,Caroline Pot,Renaud Pasquier,Claudio Gobbi,Chiara Zecca,Heinz Wiendl,Johanna Lieb,Christina Lamers,Ludwig Kappos,Marten Trendelenburg,David Leppert,Cristina Granziera,Jens Kühle,Jan Lünemann
+36 authors
,Jens KuhlePublished
Jan 3, 2025
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Abstract
Levels of activated complement proteins in the CSF are increased in people with multiple sclerosis (MS) and are associated with clinical disease severity. In this study, we determined whether complement activation profiles track with quantitative MRI metrics and liquid biomarkers indicative of disease activity and progression.
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