Restless legs syndrome (RLS) is a common neurological disorder in clinical practice, particularly prominent among hemodialysis patients. RLS severely impacts patients’ sleep quality and mental state, exacerbating their pre-existing physical discomfort and life burden. Current pharmacological treatments often yield suboptimal results and carry numerous adverse effects. Consequently, combining evidence-based nursing with rehabilitation therapy has emerged as a promising intervention strategy. Rehabilitation therapy, a multimodal non-pharmacological treatment, aims to enhance patients’ physical and psychological health, while evidence-based nursing emphasizes individualized, scientifically grounded nursing interventions. The integration of these two approaches not only alleviates RLS symptoms but also improves patients’ quality of life and self-management abilities. Based on this, the paper conducts an in-depth study of the pathogenesis and clinical characteristics of RLS in hemodialysis patients and provides a detailed analysis of the combined application of rehabilitation therapy and evidence-based nursing for this condition.
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